Figure 5
Nur77 overexpression in RAW264.7 cells reduces oxLDL-induced inflammatory cytokine synthesis. Sandwich ELISA analysis of TNF-α (A) and IL-12 (C) for the supernatants of oxLDL-treated RAW264.7 cells stably expressing GFP, GFP-Nur77, GFP-Nur77-ΔTAD or GFP-Nur77-ΔDBD. Data represent mean ± SD of three independent experiments for 1 × 106 cells, *p <0.05 compared with GFP-expressing control cell. (B) and (D) showed the level of TNF-α and IL-12 in GFP-expressing control cells with or without stimulated by oxLDL or LPS, respectively. The bars represent mean ± SD from three experiments. *p <0.05 compared with control cells.