Table 1 Description of included inflammatory disorders
From: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases
Inflammatory disorder | Inclusion criteria | Exclusion criteria |
|---|---|---|
Crohn’s disease | Compatible endoscopic and histopathologic findings | - |
Exacerbation | ||
Before first TNFα-antagonist infusion | ||
Rheumatoid arthritis | Fulfilling the 2010 ACR RA and 1987 RA criteria | - |
DAS28 >3.2 | ||
Gout | Acute arthritis | - |
Urate crystal positive or previously diagnosed gout | ||
Autoinflammatory syndrome | Known history of autoinflammatory disorder | - |
Typical attack | ||
Pancreatitis [20] | Acute characteristic epigastric pain | HIV |
SIRS [17] | Neutropenia (<1000/mm3) | |
Serum and urinary amylase levels ≥3 x ULN | Chronic corticosteroid use | |
Compatible imaging (CT or ultrasound) findings | ||
Infectious mononucleosis [16] | Compatible clinical signs | - |
EBV (VCA) or CMV IgM positive | ||
Measles [15] | Febrile rash | - |
Measles IgM positive | ||
Viral respiratory tract infection | Symptoms/signs of respiratory tract infection | Positive sputum or blood culture |
Positive PCR from respiratory tract secretions | ||
Respiratory co-infections | Symptoms/signs of respiratory tract infection | - |
Positive PCR from respiratory tract secretions | ||
Positive sputum or blood culture | ||
Bacterial sepsis [17] | International sepsis definition [17] | HIV |
Neutropenia (<1000/mm3) | ||
Candidemia [19] | Positive blood culture for Candida | - |