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Figure 1 | BMC Immunology

Figure 1

From: ImmunoGlobulin galaxy (IGGalaxy) for simple determination and quantitation of immunoglobulin heavy chain rearrangements from NGS

Figure 1

Diagram of the Immunoglobulin Heavy chain and the regions that are sequenced. (A) Schematic representation of an immunoglobulin protein. The V, D and J part form the variable domain and the C part forms the constant domain of the protein. (B) IGH rearrangements are amplified using a forward primer in the V gene and a reverse primer in the J gene. The CDR3 region consisting of part of the V gene, the D gene and part of the J gene is indicated. The red arrows represent the region that is sequenced by 454.

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BMC Immunology

ISSN: 1471-2172

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