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Figure 6 | BMC Immunology

Figure 6

From: Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM

Figure 6

Human PBLs transduced with the EpCAM-specific CAR inhibit PC3 tumor metastasis in vivo . A) A diagram is displayed of the experimental model. NOD/SCID mice were injected intravenously with 5 × 106 PC3-luc cells on day 0, followed 6 h later by intravenous injection of 5 × 106 PBLs transduced with either the EpCAM-specific CAR or a control vector. Mice without treatment were used as controls. Anti-tumor activity was determined by luminescence imaging on days 13, 20, and 27. B) Representative luminescence images of PC3-luc tumor-bearing mice with or without PBL treatment. C) Quantitative results of the PC3-luc luminescence intensity from tumor-bearing mice treated with or without PBLs. Statistical analysis was performed using a two-way analysis of variance. D) Kaplan–Meier survival analysis of PC3-luc tumor-bearing mice with different PBL treatments. A comparison of the survival curves was made using a Log-rank test.

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