Effect of MAb 5261-muIg on relapsing-remitting EAE in SJL/J mice. Mice (n = 15 per group) were treated starting on day 7 post-PLP139–151/CFA immunization with 30 mg/kg of MAb 5261-muIg or an isotype control antibody i.p., once a week for 8 weeks. (A) Average EAE scores during the course of the disease. (B) Group mean scores (GMS). Statistical significance was evaluated using unpaired Student’s t-test. *P < 0.1; ****P < 0.0001.