Heat map and unsupervised hierarchical clustering of miRNAs in IBD colon biopsies indicate dysregulation of miRNA expression. The miRCURY LNA microarray microRNA profiling service was used to examine miRNA expression in colon biopsies from Normal, CD, and UC subjects. (A) Heat map of fold changes > 0.5. (B) Heat map of fold changes > 3.0. Red color represents an expression level above mean, blue color represents expression lower than the mean. A Delta Log Median ratio of +/−1.0 is equal to a fold change of +/− 2.0.