miRNA expression is differentially expressed in matched colon biopsies from Crohn’s disease subjects. Total RNA was isolated from matched endoscopically uninvolved (EU) and endoscopically involved (EI) colon biopsies from CD subjects. The RNA samples were used for TaqMan qRT-PCR analysis for the indicated miRNAs. miRNA expression was normalized to U6 expression. Pairings were subdivided according to miRNA expression trends. Statistical significance was calculated using the Student’s paired t-test relative to the endoscopically uninvolved CD tissue.