Figure 5
From: MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis
Roquin-1 and ATG16L1 expression is differentially expressed in a subset of CD and UC subjects. Total RNA from matched endoscopically uninvolved (EU) and endoscopically involved (EI) colon biopsies from (A, C) CD and (B, D) UC subjects was used to analyze Roquin-1 or ATG16L1 expression via qRT-PCR. Gene expression was normalized to GAPDH. Pairings were subdivided according to Roquin-1 or ATG16L1 expression trends. Statistical significance was calculated using the Student’s paired t-test relative to the endoscopically uninvolved IBD tissue.