Skip to main content

Table 2 Allele, genotype, and haplotype of Th1, Th2, and Th17 cytokine polymorphisms signficantly associated with LTBI and TB

From: Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

   HC LTBI PTB LTBI.VS.HCS PTB.vs.LTBI  
   N(%) N(%) N(%) OR(95%CI) p value OR(95%CI) p value
IFN-r Genotypes        
+874(A/T) AA 212(44.2) 126(52.5) 74(61.7) 1.39(1.011–1.930) 0.035* 1.46(0.910–2.337) 0.099
  AT 201(41.9) 88(36.7) 36(30.0) 0.80(0.576–1.119) 0.131 0.74(0.448–1.213) 0.210
  TT 67(14.0) 26(10.8) 10(8.3) 0.75(0.443–1.235) 0.171 0.75(0.311–1.676) 0.456
  Alleles        
  A 625(65.1) 340(70.8) 184(76.7) 1.30(1.020–1.664) 0.029* 1.35(0.934–1.974) 0.097
  T 335(34.9) 140(29.2) 56(23.3) 0.77(0.601–0.980) 0.029* 0.74(0.507–1.071) 0.097
CA repeats Alleles        
  12 641(66.8) 340(70.8) 186(77.5) 1.21(0.946–1.547) 0.119 1.71(1.074–2.728) 0.017*
  Non-12 319(33.2) 140(29.2) 54(22.5) 0.83(0.647–1.057) 0.119 0.58(0.367–0.931) 0.017*
Haplotypes         
(+874 and CA repeats) A-12 167(17.4) 103(21.5) 60(25.0) 1.30(0.975–1.721) 0.063 1.22(0.847–1.757) 0.284
  T-12 174(18.1) 75(15.6) 30(12.5) 0.84(0.613–1.134) 0.237 0.77(0.472–1.238) 0.263
  A-non12 324(33.8) 175(36.5) 98(40.8) 1.13(0.889–1.425) 0.309 1.20(0.864–1.672) 0.254
  T-non12 295(30.7) 127(26.5) 52(21.7) 0.81(0.629–1.043) 0.093 0.77(0.521–1.126) 0.161
TNF-α Haplotypes        
(238,308,488) A-A-A 1(0.2) 1(0.4) 0(0) 1.996(0.124–32.047) 1.000 -
  A-A-G 205(42.7) 102(42.5) 0(0) 0.984(0.720–1.346) 0.922 0.54(0.477–0.599) 0.000*
  A-G-A 0(0) 0(0) 43(35.8)   4.12(3.390–5.000) 0.000*
  A-G-G 20(4.2) 10(4.2) 12(10.0) 0.996(0.459–2.162) 0.880 2.56(1.071–6.099) 0.029*
  G-A-A 1(0.2) 1(0.4) 0(0) 1.996(0.124–32.047) 1.000  
  G-A-G 13(2.7) 7(2.9) 53(44.2) 1.075(0.423–2.730) 0.880 26.33(11.439–60.61) 0.000*
  G-G-A 210(43.8) 105(43.8) 5(4.2) 0.993(0.727–1.356) 0.963 0.06(0.022–0.142) 0.000*
  G-G-G 30(6.3) 15(6.3) 7(5.8) 0.996(0.525–1.888) 0.989 0.93(0.368–2.344) 0.876
IL2 Genotype        
−330(T/G) GG 44(9.2) 29(12.1) 30(25.0) 1.210(0,742–1.969) 0.445 2.43(1.376–4.275) 0.002*
  GT 256(53.3) 104(43.3) 56(46.7) 0.669(0.489–0.914) 0.011* 1.14(0.737–1.777) 0.549
  TT 180(37.5) 107(44.6) 34(28.3) 1.34(0.966–1.858) 0.067 0.49(0.297–0.806)* 0.003*
  Alleles        
  G 344(35.8) 162(33.8) 116(48.3) 0.91(0.724–1.149) 0.435 1.84(1.339–2.519) 0.000*
  T 616(64.2) 318(66.2) 124(51.7) 1.10(0.865–1.391) 0.435 0.545(0.392–0.757)* 0.000*
−330 and −160 Haplotypes        
  G-G 205(21.4) 97(20.3) 48(20.1) 0.93(0.703–1.232) 0.615 0.99(0.655–1.475) 0.948
  G-T 99(10.3) 68(14.1) 32(13.5) 1.44(1.015–2.021) 0.031* 0.93(0.573–1.493) 0.761
  T-G 339(41.6) 95(39.5) 95(39.4) 0.45(0.344–0.590) 0.000* 2.66(1.856–3.793) 0.000*
  T-T 317(26.7) 220(26.2) 65(27) 1.72(1.362–2.161) 0.000* 0.44(0.308–0.622) 0.000*
IL-12 genotypes        
−1188(A/C) AA 270(56.2) 162(67.5) 80(66.7) 1.62(1.154–2.269) 0.004* 0.96(0.590–1.582) 0.874
  AC 177(36.9) 65(27.1) 33(27.5) 0.66(0.460–0.933) 0.009* 1.02(0.603–1.712) 0.933
  CC 33(6.9) 13(5.4) 7(5.8) 0.78(0.367–1.55) 0.451 1.08(0.355–3.011) 0.871
  Alleles        
  A 717(74.7) 389(81.0) 193(80.4) 1.49(1.097–1.922) 0.007* 0.96(0.639–1.456) 0.841
  C 243(25.3) 91(19.0) 47(19.6) 0.69(0.520–0.911) 0.007* 1.04(0.687–1.565) 0.841
IL-10 Genotypes        
−1082(A/G) AA 262(54.6) 136(56.7) 82(68.3) 1.09(0.787–1.506) 0.596 1.65(1.016–2.699) 0.033*
  AG 196(40.8) 86(35.8) 34(28.3) 0.81(0.579–1.128) 0.195 0.71(0.425–1.168) 0.155
  GG 22(4.6) 18(7.5) 4(3.4) 1.69(0.834–3.368) 0.107 0.43(0.103–1.335) 0.120
−1082 and −819 Haplotypes        
  A-C 205(21.4) 116(24.2) 58(24.2) 1.17(0.896–1.533) 0.235 0.24(0.683–1.456) 1.000
  A-T 100(10.4) 174(36.2) 95(39.6) 4.95(3.707–6.608) 0.000* 1.15(0.826–1.604) 0.383
  G-C 400(41.7) 56(11.7) 26(10.8) 0.19(0.134–0.254) 0.000* 0.91(0.533–1.525) 0.740
  G-T 255(26.6) 134(27.9) 61(25.4) 1.07(0.830–1.378) 0.601 0.88(0.607–1.268) 0.477
IL-6 Alleles        
−174(G/C) G 674(70.2) 363(75.6) 182(75.8) 1.32(1.017–1.707) 0.031* 1.01(0.695–1.481) 0.951
  C 286(29.8) 117(24.4) 58(24.2) 0.76(0.586–0.982) 0.031* 0.99(0.675–1.439) 0.951
  genotypes        
  GG 247(51.5) 131(54.6) 66(55.0) 1.03(0.749–1.429) 0.429 1.02(0.640–1.620) 0.940
  GC 180(37.5) 101(42.1) 50(41.7) 1.21(0.871–1.681) 0.235 0.98(0.614–1.569) 0.940
  CC 53(11.0) 8(3.3) 4(3.3) 0.36(0.144–0.793) 0.000* 1.00(0.216–3.826) 1.000
  1. Notes: HC, healthy controls; LTBI, subjects with latent tuberculosis infection; PTB, patients with pulmonary tuberculosis; INF-γ, interferon γ; TNF-α, tumor necrosis factor α; IL-2, interleukin 1; IL-12, interleukin 12; IL-10, interleukin 10; IL-4, interleukin 4; IL-6, interleukin 6.
  2. *p < 0.05.