Table 2 Allele, genotype, and haplotype of Th1, Th2, and Th17 cytokine polymorphisms signficantly associated with LTBI and TB

IFN-r

Genotypes

+874(A/T)

AA

212(44.2)

126(52.5)

74(61.7)

1.39(1.011–1.930)

0.035*

1.46(0.910–2.337)

0.099

AT

201(41.9)

88(36.7)

36(30.0)

0.80(0.576–1.119)

0.131

0.74(0.448–1.213)

0.210

TT

67(14.0)

26(10.8)

10(8.3)

0.75(0.443–1.235)

0.171

0.75(0.311–1.676)

0.456

Alleles

A

625(65.1)

340(70.8)

184(76.7)

1.30(1.020–1.664)

0.029*

1.35(0.934–1.974)

0.097

T

335(34.9)

140(29.2)

56(23.3)

0.77(0.601–0.980)

0.029*

0.74(0.507–1.071)

0.097

CA repeats

Alleles

12

641(66.8)

340(70.8)

186(77.5)

1.21(0.946–1.547)

0.119

1.71(1.074–2.728)

0.017*

Non-12

319(33.2)

140(29.2)

54(22.5)

0.83(0.647–1.057)

0.119

0.58(0.367–0.931)

0.017*

Haplotypes

(+874 and CA repeats)

A-12

167(17.4)

103(21.5)

60(25.0)

1.30(0.975–1.721)

0.063

1.22(0.847–1.757)

0.284

T-12

174(18.1)

75(15.6)

30(12.5)

0.84(0.613–1.134)

0.237

0.77(0.472–1.238)

0.263

A-non12

324(33.8)

175(36.5)

98(40.8)

1.13(0.889–1.425)

0.309

1.20(0.864–1.672)

0.254

T-non12

295(30.7)

127(26.5)

52(21.7)

0.81(0.629–1.043)

0.093

0.77(0.521–1.126)

0.161

TNF-α

Haplotypes

(238,308,488)

A-A-A

1(0.2)

1(0.4)

0(0)

1.996(0.124–32.047)

1.000

–

-

A-A-G

205(42.7)

102(42.5)

0(0)

0.984(0.720–1.346)

0.922

0.54(0.477–0.599)

0.000^*

A-G-A

0(0)

0(0)

43(35.8)

–

4.12(3.390–5.000)

0.000^*

A-G-G

20(4.2)

10(4.2)

12(10.0)

0.996(0.459–2.162)

0.880

2.56(1.071–6.099)

0.029^*

G-A-A

1(0.2)

1(0.4)

0(0)

1.996(0.124–32.047)

1.000

–

G-A-G

13(2.7)

7(2.9)

53(44.2)

1.075(0.423–2.730)

0.880

26.33(11.439–60.61)

0.000*

G-G-A

210(43.8)

105(43.8)

5(4.2)

0.993(0.727–1.356)

0.963

0.06(0.022–0.142)

0.000*

G-G-G

30(6.3)

15(6.3)

7(5.8)

0.996(0.525–1.888)

0.989

0.93(0.368–2.344)

0.876

IL2

Genotype

−330(T/G)

GG

44(9.2)

29(12.1)

30(25.0)

1.210(0,742–1.969)

0.445

2.43(1.376–4.275)

0.002*

GT

256(53.3)

104(43.3)

56(46.7)

0.669(0.489–0.914)

0.011^*

1.14(0.737–1.777)

0.549

TT

180(37.5)

107(44.6)

34(28.3)

1.34(0.966–1.858)

0.067

0.49(0.297–0.806)*

0.003*

Alleles

G

344(35.8)

162(33.8)

116(48.3)

0.91(0.724–1.149)

0.435

1.84(1.339–2.519)

0.000*

T

616(64.2)

318(66.2)

124(51.7)

1.10(0.865–1.391)

0.435

0.545(0.392–0.757)*

0.000*

−330 and −160

Haplotypes

G-G

205(21.4)

97(20.3)

48(20.1)

0.93(0.703–1.232)

0.615

0.99(0.655–1.475)

0.948

G-T

99(10.3)

68(14.1)

32(13.5)

1.44(1.015–2.021)

0.031*

0.93(0.573–1.493)

0.761

T-G

339(41.6)

95(39.5)

95(39.4)

0.45(0.344–0.590)

0.000*

2.66(1.856–3.793)

0.000*

T-T

317(26.7)

220(26.2)

65(27)

1.72(1.362–2.161)

0.000*

0.44(0.308–0.622)

0.000*

IL-12

genotypes

−1188(A/C)

AA

270(56.2)

162(67.5)

80(66.7)

1.62(1.154–2.269)

0.004*

0.96(0.590–1.582)

0.874

AC

177(36.9)

65(27.1)

33(27.5)

0.66(0.460–0.933)

0.009*

1.02(0.603–1.712)

0.933

CC

33(6.9)

13(5.4)

7(5.8)

0.78(0.367–1.55)

0.451

1.08(0.355–3.011)

0.871

Alleles

A

717(74.7)

389(81.0)

193(80.4)

1.49(1.097–1.922)

0.007*

0.96(0.639–1.456)

0.841

C

243(25.3)

91(19.0)

47(19.6)

0.69(0.520–0.911)

0.007*

1.04(0.687–1.565)

0.841

IL-10

Genotypes

−1082(A/G)

AA

262(54.6)

136(56.7)

82(68.3)

1.09(0.787–1.506)

0.596

1.65(1.016–2.699)

0.033*

AG

196(40.8)

86(35.8)

34(28.3)

0.81(0.579–1.128)

0.195

0.71(0.425–1.168)

0.155

GG

22(4.6)

18(7.5)

4(3.4)

1.69(0.834–3.368)

0.107

0.43(0.103–1.335)

0.120

−1082 and −819

Haplotypes

A-C

205(21.4)

116(24.2)

58(24.2)

1.17(0.896–1.533)

0.235

0.24(0.683–1.456)

1.000

A-T

100(10.4)

174(36.2)

95(39.6)

4.95(3.707–6.608)

0.000^*

1.15(0.826–1.604)

0.383

G-C

400(41.7)

56(11.7)

26(10.8)

0.19(0.134–0.254)

0.000^*

0.91(0.533–1.525)

0.740

G-T

255(26.6)

134(27.9)

61(25.4)

1.07(0.830–1.378)

0.601

0.88(0.607–1.268)

0.477

IL-6

Alleles

−174(G/C)

G

674(70.2)

363(75.6)

182(75.8)

1.32(1.017–1.707)

0.031^*

1.01(0.695–1.481)

0.951

C

286(29.8)

117(24.4)

58(24.2)

0.76(0.586–0.982)

0.031^*

0.99(0.675–1.439)

0.951

genotypes

GG

247(51.5)

131(54.6)

66(55.0)

1.03(0.749–1.429)

0.429

1.02(0.640–1.620)

0.940

GC

180(37.5)

101(42.1)

50(41.7)

1.21(0.871–1.681)

0.235

0.98(0.614–1.569)

0.940

CC

53(11.0)

8(3.3)

4(3.3)

0.36(0.144–0.793)

0.000^*

1.00(0.216–3.826)

1.000