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Table 3 Association between combinations of cytokine gene polymorphisms and susceptibility to LTBI and PTB

From: Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

 

INF-γ

TNF-a

IL-10

IL-2

HC

LTBI

PTB

LTBI.vs.Health

PTB.vs.LTBI

874

−308

−1082

−330

OR(95%CI)

OR(95%CI)

1

A

A

A

G

56

30

12

1.07(0.657-1.734)

0.79(0361–1.624)

2

A

A

A

T

113

47

43

0.81(0.555-1.178)

2.01(1.252-3.219)*

3

A

A

G

T

50

41

5

1.70(1.079-2.665)*

0.23(0.069-0.588)

4

A

G

A

G

70

32

22

9.25(5.300-15.932)*

1.41(1.062-2.575)*

5

A

G

A

T

105

67

46

1.32(0.936-1.855)

1.46(0.994-2.248)

6

A

G

G

G

29

28

7

1.98(1.125-3.505)*

0.48(0.176-1.159)

7

A

G

G

T

44

26

11

1.19(0.695-2.009)

0.84(0.367-1.795)

8

T

A

A

G

29

20

9

2.47(1.300-4.599)*

0.89(0.353-2.101)

9

T

A

A

T

64

32

11

1.00(0.623-1.578)

0.67(0.300-1.400)

10

T

A

G

G

35

11

7

0.62(0.281-1.263)

0.33(0.107-1.945)

11

T

A

G

T

71

30

8

0.83(0.518-1.319)

0.52(0.202-1.179)

12

T

G

A

G

24

19

9

1.61(0.823-3.093)

0.95(0.371-2.236)

13

T

G

A

T

85

43

17

1.01(0.673-1.508)

0.77(0.405-1.425)

14

T

G

G

G

38

20

6

1.05(0.574-1.884)

0.59(0.191-1.550)

15

T

G

G

T

124

28

16

0.42(0.263-0.645)

1.15(0.570-2.259)

  1. Notes: HC, healthy controls; LTBI, subjects with latent tuberculosis infection; PTB, patients with pulmonary tuberculosis; INF-γ, interferon γ; TNF-α, tumor necrosis factor α; IL-10, interleukin 10; IL-2, interleukin 2.
  2. *p < 0.05.