Evaluation of immunomodulatory activities of methanolic extract of khat (Catha edulis, Forsk) and cathinone in Swiss albino mice

Table 2 Effect of cathinone and crude khat extract on hematological parameters (mean ± SEM) of mice (n = 6)

Dose (mg/kg)	*RBC106/μL**	HB (g/dL)	HCT (%)	MCV (FL)	MCH (pg)	MCHC (g/dL)	*Platelet10 ³ /μL**
Cathinone
Control	8.07 ± 0.3	12.82 ± 0.47	44.3 ± 0.67	54.85 ± 0.03	15.76 ± 0.047	30.91 ± 0.13	884 ± 26
0.625	7.68 ± 0.15	12.51 ± 0.27	40.6 ± 0.14	52.82 ± 0.46	16.28 ± 0.042	30.82 ± 0.2	694 ± 16*
1.25	8.72 ± 0.15	13.7 ± 0.23	43.5 ± 0.78	52.2 ± 0.00	15.63 ± 0.067	30.1 ± 0.0	628 ± 12*
2.5	8.92 ± 0.64	12.1 ± 1.04	40.7 ± 0.23	51.4 ± 0.11**	15.25 ± 0.086	29.65 ± 0.2*	581 ± 23*
5	8.07 ± 0.31	12.12 ± 0.04	44.2 ± 0.67	51.8 ± 0.03**	15.55 ± 0.047	28.7 ± 0.13*	509 ± 48*
Khat
50	8.3 ± 0.72	12.7 ± 1.11	43.3 ± 1.06	52.06 ± 1.5	15.67 ± 0.31	29.52 ± 0.53	670 ± 12.7
100	8.7 ± 0.25	13.6 ± 0.45	46.1 ± 1.94	52.9 ± 1.36	15.23 ± 0.02	29.42 ± 0.25	639 ± 27.6*
200	8.63 ± 0.37	12.66 ± 0.25	43 ± 1.71	51.66 ± 1.4*	15.63 ± 0.07	29.53 ± 0.15	543 ± 42*

NB: Values with asterisk are significantly different: * = P < 0.05, ** = P < 0.01 (ANOVA, Tukey’s HSD post-hoc test) from values of control.

ISSN: 1471-2172