Evaluation of immunomodulatory activities of methanolic extract of khat (Catha edulis, Forsk) and cathinone in Swiss albino mice

Table 3 Delay type hypersensitivity responses (Mean ± SEM) in mice (n = 6) treated with crude khat extract and cathinone

Substance	Dose (mg/Kg)	DTH response (mm) mean paw edema
Cathinone	Control	4.75 ± 0.857
	Positive control (Dexamethason)	0.04 ± 0.02
	0.625 mg/kg	4.71 ± 0.57
	1.25 mg/kg	5.1 ± 0.51
	2.5 mg/kg	6.06 ± 0.37*
	5 mg/kg	6.56 ± 0.97**
Khat	50 mg/kg	8.06 ± 0.91**
	100 mg/kg	7.26 ± 1.17**
	200 mg/kg	3.2 ± 0.775*

NB: Values with asterisk are significantly different (ANOVA, Tukey’s HSD post-hoc test) from values of control: * = P < 0.01, ** = P < 0.001.

ISSN: 1471-2172