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Figure 6 | BMC Immunology

Figure 6

From: C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis

Figure 6

Effects of mCRP on D-dimer formation and HMGB-1 secretion. A: Effects of mCRP on the D-dimer formation. White columns: D-dimer levels of plasma after ANCA-induced netting neutrophils were statically incubated with pCRP-containing PRP or mCRP-containing PRP. Gray columns: D-dimer levels of plasma after ANCA-induced netting neutrophils were perfused with pCRP-containing PFP or mCRP-containing PFP. Black columns: D-dimer levels of plasma after ANCA-induced netting neutrophils were perfused with pCRP-containing PRP or mCRP-containing PRP. All experiments were performed in triplicate. B: Effects of mCRP on the HMGB-1 secretion of platelets. White columns: HMGB-1 levels of plasma after isolated NETs were statically incubated with pCRP-containing PRP or mCRP-containing PRP. Gray columns: HMGB-1 levels of plasma after isolated NETs were perfused with pCRP-containing PFP or mCRP-containing PFP. Black columns: HMGB-1 levels of plasma after isolated NETs were perfused with pCRP-containing PRP or mCRP-containing PRP. All experiments were performed in triplicate.

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BMC Immunology

ISSN: 1471-2172

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