Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

Borhis, Gwenoline; Richard, Yolande

doi:10.1186/s12865-015-0079-y

BMC Immunology

Table 1 Summary of the main changes in B-cell subsets during parasite and viral infections

From: Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

PATHOGENS
	Plasmodium falciparum or vivax	Schistosomia haematobium	Mycobacterium tuberculosis	HIV-1 /SIV	HCV	HBV
*Circulating BAFF levels*	Elevated Reduced BAFF-R expression	ND	ND	Increased during acute phase. Associated to B-cell lymphoma (chronic phase)	ND	ND
*Frequencies of B-cell subsets*
Immature-transtional CD10 ⁺ IgM ^hi IgD ⁺ CD27 ⁻	Increased	ND	ND	Increased (chronic)	ND	ND
MZ IgM ^hi IgD ⁺ CD27 ⁺	Reduced	Unchanged	ND	Decrease	ND	ND
Naive IgM ⁺ IgD ^hi CD27 ⁻ CD21int	ND	Decreased	ND	Variable	Variable	ND
Resting Mem IgD ⁻ CD27 ⁺ CD21 ⁺	Decreased	Unchanged	ND	Decreased	Decreased	ND
Activated Mem IgD ⁻ CD27 ⁺ CD21 ⁻	ND	Increased	ND	Increased	ND	ND
Atypical Mem SIgG/A ⁺ CD27 ^- CD21 ⁻	increased FcRL4⁺, Polysaccharide IgG	Increased	ND	Increased FcRL4⁺ virus-specific Abs?	Increased, CD95⁺ IgG producers	ND
Regulatory B-cells	CD10⁺ Increased?	CD1d^hi, IL10⁺, Induce T-reg Suppress IFNγ and IL17 production	CD1d^hiCD5⁺, no IL10 or TGFβ Suppression of IL17/22 through cognate interactions	CD38^hiCD24^hiCD27^- IL10⁺, Suppress HIV-specific CD8 T-cell responses	ND	CD38^hiCD24^hiCD27^- IL10⁺, Suppress HIV-specific CD8 T-cell responses
Regulatory B-cells	CD10⁺ Increased?	CD24^hiCD27⁺ Produce TGFβ and induce Treg			ND
*Additionnal Remarks*	Pregenany exacerbates atypical Mem expansion	Impaired TNFα production by B-cells, even in treated patients	Impaired responses of monocytes & CD11c ⁺ DC	Impaired fonctions of DC	Impaired responses of monocytes & DC	Impaired responses of monocytes & DC
	T-cell hyporesponsiveness	Impaired responses of CD11c ⁺ DC T-cell hyporesponsiveness	T-cell hyporesponsiveness	Increased in Slan DC	Impaired CD8 T-cell responses	Impaired CD8 T-cell responses
	T-cell hyporesponsiveness	Impaired responses of CD11c ⁺ DC T-cell hyporesponsiveness	T-cell hyporesponsiveness	Strong depletion of CD4 T-cells Impaired CD8 T-cell responses	Impaired CD8 T-cell responses	Impaired CD8 T-cell responses

Abs: antibodies; DC: dendritic cells; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; Mem: memory; MZ: marginal zone; ND: Not documented; T-reg: regulatory T-cells; SIV: simian immunodeficiency virus.

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ISSN: 1471-2172

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