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Figure 1 | BMC Immunology

Figure 1

From: All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β

Figure 1

Graft survival curve. Each group contained at least 30 recipient mice at 14 days, 20 mice at 28 days and 10 mice at 56 days postoperative. The curve represents the average survival rate of each group. At the early time point (10–21 days), the grafts treated with either ATRA alone or the combination of ATRA and TGF-β had a modestly higher survival rate (100%) than those treated with a control solution (82%). Nevertheless, a single administration of TGF-β did not promote graft survival at an early stage following surgery. In contrast, at a late time point (35–56 days), the survival rate of grafts treated with either ATRA or TGF-β solely was significantly higher than controls (ATRA: 65% and TGF-β: 60% vs control: 48%). A mixed administration of ATRA and TGF-β further promoted graft survival rate to 82%.

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