Figure 6

Gene expression of Foxp3, RORγt and RORα in the grafts and PBMCs. At 2wks postsurgery, a mixed treatment of ATRA and TGF-β significantly promoted the Foxp3 expression in PBMCs and suppressed the RORγt expression as well. At 4wks, the Foxp3 expression increased significantly in the allogeneic grafts either with a mixed treatment or ATRA alone, and the reduced expression of RORγt was likewise found in these two groups. At each time point, each group contained at least five corneas and three blood samples. Data are presented as the mean value ± standard error and are representative of at least two independent experiments. * P < 0.05.