Figure 2

3D-plots representing the mean index value reactivity in each individual study group. A) DTPwc: children who received the Diphtheria Tetanus Pertussis whole cell vaccine; B) DTPa5: Diphtheria Tetanus Pertussis 5 components vaccine; C) DTPa2: i Diphtheria Tetanus Pertussis 2 components vaccine; D) Whooping cough: children who received the placebo and developed natural infection; E) DT: children vaccinated the placebo, who did not develop whooping cough. The proteins on the microarray are aligned the : 1 - P.69A protein (pertactin); 2 - Bordetella resistance to killing; 3 - Tracheal colonization factor; 4 - Vag8 protein (Autotransporter); 5 - Pertussis toxin subunit 1 precursor; 6 - Pertussis toxin subunit 2 precursor; 7 - Pertussis toxin subunit 3 precursor; 8 - Pertussis toxin subunit 4 precursor; 9 - Pertussis toxin subunit 5 precursor; 10 - Bifunctional hemolysin-adenylate cyclaseprecursor; 11 - Filamentous hemagglutinin; 12 - Fim2 pilic subunit; 13 - Serotype 3 fimbrial subunit precursor; 14 - Outer membrane porin protein precursor; 15 - Outer membrane porin protein OmpQ; 16 - GTP-binding elongation factor; 17 - putative autotransporter. The DTPwc and the DTPa5 vaccines were similar to the pattern obtained from serum from children diagnosed wth whooping cough, while the DTPa2 group showed a shape similar to the IgG recognition pattern detected in the DT group.