Figure. 3
Differential target epitope recognition in patients with whooping cough. Figure 3A: 3D-plots representing the differential mean index value in the whooping cough (left panel) and DTPa2 (right panel) groups as compared to the reference the mean index value in the DT group. Figure 3B: Inclusive/exclusive analysis of serum reactivity from children in the whooping cough (left panel) and DTPa2 (right panel) groups vs. the DT (control) group. These peptides are exclusively recognized in the respective test group at the indicated frequency (e.g. 10/10 serum samples) and never in serum from any individual in the DT group. 12 peptides were strongly recognized in serum from at least 8 out 10 of the children developing whooping cough; 8 peptides were highly recognized in serum from at least 8 out of 10 infants in the DTPa2 group. No specific pattern of recognition was detected by the inclusive/exclusive analysis in the other study groups. DTPa2: infants who received the Diphtheria Tetanus Pertussis 2 components vaccine, DT: infants not vaccinated and who did tno developed whooping cough.