Neutralization Profiles. The neutralization profile from CL3 is provided along with results for two other established HIV neutralizing HuMabs (2F5 and 2G12). A CL3 and 2F5 are compared against the negative control, a control human monocolonal antibody. B CL3 and 2F5 are compared against the positive control, 2G12. The concentration of CL3 that inhibits 50% of cellular infections by the 92 BR030 isolate was 2 μg/ml, while the same value for 2F5 was 10 μg/ml. This indicates that, at least for this HIV-1 isolate, CL3 is more effective than 2F5 at neutralizing infection (p < 0.05).