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Fig. 7 | BMC Immunology

Fig. 7

From: Morphological change of CD4+ T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse

Fig. 7

F-actin modulated the distribution of mitochondria. a The localisation of mitochondria (blue) in an elongated and/or flattened CD4+ or a CD4+ T cell with cytochalasin D treatment. TCR (red) and LFA-1 (green) were labelled to show the IS formation. The dotted white line depicts the contact boundary between the CD4+ T cells and the DCs. Scale bar = 2 μm. b Left column: The percentage of CD4+ T cells with mitochondrial localisation in the IS. Right column: The MFI of mitochondria in the IS in CD4+ T cells (mean ± s.e.m., n=25, three independent experiments), **P<0.01, ***P<0.001 (two-tailed Student’s t-test)

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BMC Immunology

ISSN: 1471-2172

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