Fig. 4
From: Swainsonine exposure induces impairment of host immune response in pregnant BALB/c mice
Flow cytometry of Th1/Th2 cytokines between four groups and control group (0 mg•kg−1•d−1) at baseline. As showed in the Fig. 3a and b, the Th1/Th2 balance of pregnant mice was imbalanced, respectively. a Were the intracellular cytokine expression of Th1 and Th2. The X-axis were the expression of IL-4 and the Y-axis were the expression of IFN-γ. b Were the Th1/Th2 of each group. Different dose of swainsonine can significantly effect Th1/Th2 balance. In the dose of 0.2 mg•kg−1•d−1 or higher dose, Th1 cell were promoted and Th2 were inhibited, especially in the dose of 1.6 mg•kg−1•d−1. Swainsonine-treaded mice showed Th1 dominant that is detrimental to pregnancy