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Table 1 Comparison of the medians (Interquartile Range) of various cell type subsets at different time points

From: Proportions of CD4+, CD8+ and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children

Cell Type or Ratio 6 Months 12 Months 18 Months
HEU HUU p HEU HUU p HEU HUU p
Total CD4+ T cells 55.20 (47.50 - 62.80) 58.40 (55.20 – 67.50) 0.04 54.80 (42.70 – 59.30) 51.10 (44.60 – 54.90) 0.62 54.80 (47.70 – 58.70) 48.80 (39.50 – 55.30) 0.05
Effector memory CD4+ T cells 6.8 (5.13 – 9.29) 6.47 (4.38 – 8.93) 0.53 9.7 (6.01 – 13.2) 7.64 (5.30 – 10.2) 0.19 11.9 (10.2 – 14.7) 12.1 (9.24 – 16.5) 0.89
CD4:CD8 Ratio 1.57 (1.16 – 2.18) 1.79 (1.47 – 2.54) 0.08 1.50 (1.00 – 1.90) 1.30 (1.05 – 1.78) 0.64 1.51 (1.10 – 1.92) 1.18 (0.80 - 1.63) 0.05
CD8+ T cells Subsets Total CD8+ T 35.10 (29.0 – 42.3) 32.60 (27.40 – 36.40) 0.15 36.40 (31.20 – 43.40) 39.30 (31.50 – 43.40) 0.63 36.70 (30.60 – 39.90) 41.70 (33.20 – 47.90) 0.05
Naïve 41.40 (27.6 – 51.3) 52.60 (36.50 – 67.50) 0.02 46.60 (33.50 – 56.80) 40.50 (33.40 – 64.20) 0.88 43.80 (36.00 – 53.30) 38.40 (26.70 – 48.50) 0.17
Central memory 1.94 (1.37 – 3.24) 2.11 (1.80 – 3.63) 0.38 1.48 (0.94 – 2.68) 1.48 (1.01 – 2.68) 0.82 1.17 (0.67 – 1.62) 1.08 (0.74 – 2.16) 0.75
Effector memory 19.50 (14.90 – 25.30) 14.30 (7.65 – 22.8) 0.04 14.10 (8.51 – 20.0) 13.70 (8.68 – 19.0) 0.89 11.20 (7.37 – 15.6) 14.10 (8.85 – 18.0) 0.28
Terminal Effector 32.50 (21.50 – 44.80) 27.40 (12.1 – 42.3) 0.15 37.40 (17.50 – 49.30) 37.20 (20.20 – 47.80) 0.96 41.60 (32.60 – 49.40) 44.70 (34.50 – 57.00) 0.29
B cells Subsets Total CD19+ B cells 23.30 (16.10 – 29.80) 20.7 (16.8 – 29.10) 0.91 20.70 (13.70 – 29.10) 20.90 (15.20 – 27.40) 0.98 20.10 (14.10 – 25.50) 18.80 (12.60 – 27.30) 0.91
Naïve 83.10 (79.20 – 85.60) 83.16 (80.70 – 87.90) 0.35 77.15 (71.20 – 78.90) 73.55 (70.60 – 81.90) 0.98 70.75 (66.40 – 77.20) 71.53 (63.20 – 74.00) 0.45
Immature/Transitional 5.14 (2.14 – 7.11) 3.78 (2.21 – 5.09) 0.12 2.35 (1.39 – 4.19) 3.38 (1.70 – 4.54) 0.32 3.63 (2.26 – 6.98) 4.39 (2.41 – 5.47) 0.91
Classical Memory 5.98 (5.29 – 6.73) 5.26 (4.59 – 7.85) 0.58 12.11 (9.09 – 13.30) 12.27 (8.68 – 14.4) 0.92 12.72 (10.2 – 15.6) 13.05 (10.20 – 15.20) 0.95
Activated Memory 1.32 (0.77 – 2.41) 1.37 (0.85 – 2.16) 0.98 3.21 (2.12 – 3.85) 2.77 (1.64 – 3.78) 0.36 3.17 (2.42 – 4.53) 4.00 (3.17 – 5.22) 0.12
Atypical Memory 3.96 (2.65 – 6.17) 4.21 (2.75 – 5.65) 0.91 5.99 (2.86 – 7.78) 5.86 (3.84 – 7.77) 0.91 6.38 (4.28 – 9.34) 7.53 (4.28 – 11.6) 0.34
  1. The p values presented in bold indicate statistically significant differences between the HEU and HUU values for each cell type