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Table 1 Comparison of the medians (Interquartile Range) of various cell type subsets at different time points

From: Proportions of CD4+, CD8+ and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children

Cell Type or Ratio

6 Months

12 Months

18 Months

HEU

HUU

p

HEU

HUU

p

HEU

HUU

p

Total CD4+ T cells

55.20 (47.50 - 62.80)

58.40 (55.20 – 67.50)

0.04

54.80 (42.70 – 59.30)

51.10 (44.60 – 54.90)

0.62

54.80 (47.70 – 58.70)

48.80 (39.50 – 55.30)

0.05

Effector memory CD4+ T cells

6.8 (5.13 – 9.29)

6.47 (4.38 – 8.93)

0.53

9.7 (6.01 – 13.2)

7.64 (5.30 – 10.2)

0.19

11.9 (10.2 – 14.7)

12.1 (9.24 – 16.5)

0.89

CD4:CD8 Ratio

1.57 (1.16 – 2.18)

1.79 (1.47 – 2.54)

0.08

1.50 (1.00 – 1.90)

1.30 (1.05 – 1.78)

0.64

1.51 (1.10 – 1.92)

1.18 (0.80 - 1.63)

0.05

CD8+ T cells Subsets

Total CD8+ T

35.10 (29.0 – 42.3)

32.60 (27.40 – 36.40)

0.15

36.40 (31.20 – 43.40)

39.30 (31.50 – 43.40)

0.63

36.70 (30.60 – 39.90)

41.70 (33.20 – 47.90)

0.05

Naïve

41.40 (27.6 – 51.3)

52.60 (36.50 – 67.50)

0.02

46.60 (33.50 – 56.80)

40.50 (33.40 – 64.20)

0.88

43.80 (36.00 – 53.30)

38.40 (26.70 – 48.50)

0.17

Central memory

1.94 (1.37 – 3.24)

2.11 (1.80 – 3.63)

0.38

1.48 (0.94 – 2.68)

1.48 (1.01 – 2.68)

0.82

1.17 (0.67 – 1.62)

1.08 (0.74 – 2.16)

0.75

Effector memory

19.50 (14.90 – 25.30)

14.30 (7.65 – 22.8)

0.04

14.10 (8.51 – 20.0)

13.70 (8.68 – 19.0)

0.89

11.20 (7.37 – 15.6)

14.10 (8.85 – 18.0)

0.28

Terminal Effector

32.50 (21.50 – 44.80)

27.40 (12.1 – 42.3)

0.15

37.40 (17.50 – 49.30)

37.20 (20.20 – 47.80)

0.96

41.60 (32.60 – 49.40)

44.70 (34.50 – 57.00)

0.29

B cells Subsets

Total CD19+ B cells

23.30 (16.10 – 29.80)

20.7 (16.8 – 29.10)

0.91

20.70 (13.70 – 29.10)

20.90 (15.20 – 27.40)

0.98

20.10 (14.10 – 25.50)

18.80 (12.60 – 27.30)

0.91

Naïve

83.10 (79.20 – 85.60)

83.16 (80.70 – 87.90)

0.35

77.15 (71.20 – 78.90)

73.55 (70.60 – 81.90)

0.98

70.75 (66.40 – 77.20)

71.53 (63.20 – 74.00)

0.45

Immature/Transitional

5.14 (2.14 – 7.11)

3.78 (2.21 – 5.09)

0.12

2.35 (1.39 – 4.19)

3.38 (1.70 – 4.54)

0.32

3.63 (2.26 – 6.98)

4.39 (2.41 – 5.47)

0.91

Classical Memory

5.98 (5.29 – 6.73)

5.26 (4.59 – 7.85)

0.58

12.11 (9.09 – 13.30)

12.27 (8.68 – 14.4)

0.92

12.72 (10.2 – 15.6)

13.05 (10.20 – 15.20)

0.95

Activated Memory

1.32 (0.77 – 2.41)

1.37 (0.85 – 2.16)

0.98

3.21 (2.12 – 3.85)

2.77 (1.64 – 3.78)

0.36

3.17 (2.42 – 4.53)

4.00 (3.17 – 5.22)

0.12

Atypical Memory

3.96 (2.65 – 6.17)

4.21 (2.75 – 5.65)

0.91

5.99 (2.86 – 7.78)

5.86 (3.84 – 7.77)

0.91

6.38 (4.28 – 9.34)

7.53 (4.28 – 11.6)

0.34

  1. The p values presented in bold indicate statistically significant differences between the HEU and HUU values for each cell type