Cell Type or Ratio | 6 Months | 12 Months | 18 Months | |||||||
---|---|---|---|---|---|---|---|---|---|---|
HEU | HUU | p | HEU | HUU | p | HEU | HUU | p | ||
Total CD4+ T cells | 55.20 (47.50 - 62.80) | 58.40 (55.20 – 67.50) | 0.04 | 54.80 (42.70 – 59.30) | 51.10 (44.60 – 54.90) | 0.62 | 54.80 (47.70 – 58.70) | 48.80 (39.50 – 55.30) | 0.05 | |
Effector memory CD4+ T cells | 6.8 (5.13 – 9.29) | 6.47 (4.38 – 8.93) | 0.53 | 9.7 (6.01 – 13.2) | 7.64 (5.30 – 10.2) | 0.19 | 11.9 (10.2 – 14.7) | 12.1 (9.24 – 16.5) | 0.89 | |
CD4:CD8 Ratio | 1.57 (1.16 – 2.18) | 1.79 (1.47 – 2.54) | 0.08 | 1.50 (1.00 – 1.90) | 1.30 (1.05 – 1.78) | 0.64 | 1.51 (1.10 – 1.92) | 1.18 (0.80 - 1.63) | 0.05 | |
CD8+ T cells Subsets | Total CD8+ T | 35.10 (29.0 – 42.3) | 32.60 (27.40 – 36.40) | 0.15 | 36.40 (31.20 – 43.40) | 39.30 (31.50 – 43.40) | 0.63 | 36.70 (30.60 – 39.90) | 41.70 (33.20 – 47.90) | 0.05 |
Naïve | 41.40 (27.6 – 51.3) | 52.60 (36.50 – 67.50) | 0.02 | 46.60 (33.50 – 56.80) | 40.50 (33.40 – 64.20) | 0.88 | 43.80 (36.00 – 53.30) | 38.40 (26.70 – 48.50) | 0.17 | |
Central memory | 1.94 (1.37 – 3.24) | 2.11 (1.80 – 3.63) | 0.38 | 1.48 (0.94 – 2.68) | 1.48 (1.01 – 2.68) | 0.82 | 1.17 (0.67 – 1.62) | 1.08 (0.74 – 2.16) | 0.75 | |
Effector memory | 19.50 (14.90 – 25.30) | 14.30 (7.65 – 22.8) | 0.04 | 14.10 (8.51 – 20.0) | 13.70 (8.68 – 19.0) | 0.89 | 11.20 (7.37 – 15.6) | 14.10 (8.85 – 18.0) | 0.28 | |
Terminal Effector | 32.50 (21.50 – 44.80) | 27.40 (12.1 – 42.3) | 0.15 | 37.40 (17.50 – 49.30) | 37.20 (20.20 – 47.80) | 0.96 | 41.60 (32.60 – 49.40) | 44.70 (34.50 – 57.00) | 0.29 | |
B cells Subsets | Total CD19+ B cells | 23.30 (16.10 – 29.80) | 20.7 (16.8 – 29.10) | 0.91 | 20.70 (13.70 – 29.10) | 20.90 (15.20 – 27.40) | 0.98 | 20.10 (14.10 – 25.50) | 18.80 (12.60 – 27.30) | 0.91 |
Naïve | 83.10 (79.20 – 85.60) | 83.16 (80.70 – 87.90) | 0.35 | 77.15 (71.20 – 78.90) | 73.55 (70.60 – 81.90) | 0.98 | 70.75 (66.40 – 77.20) | 71.53 (63.20 – 74.00) | 0.45 | |
Immature/Transitional | 5.14 (2.14 – 7.11) | 3.78 (2.21 – 5.09) | 0.12 | 2.35 (1.39 – 4.19) | 3.38 (1.70 – 4.54) | 0.32 | 3.63 (2.26 – 6.98) | 4.39 (2.41 – 5.47) | 0.91 | |
Classical Memory | 5.98 (5.29 – 6.73) | 5.26 (4.59 – 7.85) | 0.58 | 12.11 (9.09 – 13.30) | 12.27 (8.68 – 14.4) | 0.92 | 12.72 (10.2 – 15.6) | 13.05 (10.20 – 15.20) | 0.95 | |
Activated Memory | 1.32 (0.77 – 2.41) | 1.37 (0.85 – 2.16) | 0.98 | 3.21 (2.12 – 3.85) | 2.77 (1.64 – 3.78) | 0.36 | 3.17 (2.42 – 4.53) | 4.00 (3.17 – 5.22) | 0.12 | |
Atypical Memory | 3.96 (2.65 – 6.17) | 4.21 (2.75 – 5.65) | 0.91 | 5.99 (2.86 – 7.78) | 5.86 (3.84 – 7.77) | 0.91 | 6.38 (4.28 – 9.34) | 7.53 (4.28 – 11.6) | 0.34 |