Table 2 Immunoexpression (mean value, ng/ml) of all studied proteins (TGF-β1, Smad-2, −3, and −7, and VEGF-A) in serum and BAL supernatant of patients with sarcoidosis
From: Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients
Immunoexpression (mean value, ng/ml) | Serum | Protein | X-ray stage I | X-ray stages II-III | Acute onset | Insidious onset |
TGF-β1 | 3.58 (1.054–6.05) | 3.40 (0.0625–6.728) | 3.45 (0.0625–6.05) | 3.53 (0.0625–6.728) | ||
Smad2 | 1.07 (0.244–4.784) | 0.89 (0.035–3.71) | 0.958 (0.035–4.784) | 1.029 (0.061–3.71) | ||
Smad3 | 0.875 (0.061–9.187) | 0.864 (0.061–6.846) | 0.908 (0.061–9.186) | 0.824 (0.061–6.846) | ||
Smad7 | 0.131 (0.058–0.681) | 0.278 (0.058–2.82) | 0.126 (0.19–0.681) | 0.278 (0.058–2.827) | ||
VEGF-A | 2.47 × 10−3 (0.55–8.25) | 2.27 × 10−3 (0.55–10.28) | 2.314 × 10−3 (0.55–8.25) | 2.44 × 10−3 (0.55–10.28) | ||
BAL fluid | TGF-β1 | 0.064 (0.062–0.081) | 0.075 (0.062–0.143) | 0.06 (0.06–0.139) | 0.07 (0.06–0.143) | |
Smad2 | not detected | not detected | not detected | not detected | ||
Smad3 | not detected | not detected | not detected | not detected | ||
Smad7 | not detected | not detected | not detected | not detected | ||
VEGF-A | 0.0055 × 10−3 (0.0055–0.006) | 0.01 × 10−3 (0.055–0.118) | 0.0056 × 10−3 (0.0055–0.0072) | 0.01 × 10−3 (0.055–0.118) |