Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV

Table 3 Patient characteristics

ID	Age	Sex	Ethnicity	HLA class I	HBeAg
C1	57	F	Black African	A2A24 B44B58 C3C16	Neg
C2	46	F	Asian	A24A31 B35B51 C1C14	Neg
C3	43	M	Arab	A2A3 B44B47 C6C16	Neg
C4	35	M	Asian	A11A33 B44B55 C3C7	Neg
C5	52	M	Asian	A2A33B40B51 C14C15	Pos
C6	33	M	White European	A2 B14B18 C7C8	Neg
C7	49	F	Asian	A1A11 B35B52 C4C7	Neg
C8	39	F	White European	A3A74B15B35 C4	Neg
C9	29	F	White European	A1A32 B40B44 C3C16	Neg
C10	65	M	White European	A2A29 B7B44 C7C16	Pos
C11	30	F	White European	A2 B38B51 C12C15	Neg
C12	26	F	White European	A2A24 B18B38 C7C12	Neg
C13	43	F	Asian	A2A26 B56B59 C1C7	Neg
C14	46	M	White European	A1A2 B37B51 C6C15	Neg
C15	73	M	White European	A2A3 B7 C7	Neg
C16	53	M	Asian	A11A24 B13B18 C3C7	Neg
C17	29	F	White European	A2 B13 C6	Neg
C18	61	F	Asian	A11A33 B13B58 C3	Neg
C19	40	F	Asian	A11A33 B44B59 C1C14	Neg
C20	51	F	Black African	A29A30 B18B45 C6C7	Pos
C21	34	F	Asian	A24A26 B13B40 C3C6	Pos
C22	30	M	White European	A2A26 B38B51 C12C15	Neg
C23	62	F	White European	A2A68 B15B44 C3C7	Neg
C24	51	M	White European	A2A3 B7B18 C7	Neg
C25	61	M	White European	A2A26 B7B51 C1C12	Neg
C26	34	F	Asian	A24A26 B13B40 C3C6	Pos
C27	61	F	White European	N/A	Neg
C28	49	M	Asian	N/A	Neg
C29	37	M	Asian	N/A	Pos
C30	23	M	White European	N/A	Neg
R31	40	F	White European	A2 B15B44 C1C5
R32	30	F	White European	A2A68 B35B44 C4C5
R33	N/A	N/A	White European	A2A26 B38B40 C12C15
R34	48	M	White European	A23A26 B35B44 C4
R35	65	F	White European	A1A2 B7B8 C7
R36	43	F	White European	A1A11 B8B15 C7
R37	38	M	White European	A2A11 B15B55 C3
R38	69	F	White European	A2 B7B8 C7
R39	73	F	White European	N/A
R40	25	F	White European	N/A

Normal ALT levels were found in all patients except patient C18 and C19 where ALT levels were elevated to 59 and 66 IU/mL (normal range for females is 10–45 IU/mL). No patients were double positive or double negative for HBeAg/anti-HBeAg. Median HBV DNA in the HBeAg positive patients were 81,000 IU/mL (2 – 400.000 IU/mL) and 0.019 IU (0 – 5500 IU/mL) in the HBV negative patients, no statistics were made on HBV genotype since quantification was not possible in 12 of the 30 patients. N/A: not available; F: female; M: male; Pos: positive; Neg: negative

ISSN: 1471-2172