Skip to main content
Fig. 1 | BMC Immunology

Fig. 1

From: Mycobacterium tuberculosis secretory proteins downregulate T cell activation by interfering with proximal and downstream T cell signalling events

Fig. 1

M. tuberculosis antigens alter free intracellular calcium concentration in PPD+ve healthy individuals and pulmonary TB patients. Peripheral blood mononuclear cells (PBMCs) from 13 PPD+ve healthy donors and five pulmonary TB patients were stimulated with M. tuberculosis antigens for 4 h. Fluorescence intensities were measured in ratio mode using Varian ECLIPSE spectrofluorometer as mentioned in material and methods. Bar diagrams show changes in [Ca2+]i in anti CD3 and ionomycin treated cells of (a) PPD+ve healthy individuals (b) Pulmonary TB patients and values in histogram are mean ± SEM. *, P < 0.05; **, P <0.005

Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us