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Fig. 1 | BMC Immunology

Fig. 1

From: Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5+ B cell expansion

Fig. 1

CD5+ B cells in dnRAG1 and DTG mice express high levels of CD1d. a-b Cohorts of 12 week-old (a) and 36 week-old (b) mice were analyzed for CD1d expression on CD19+ and CD5− or CD5+ B cells from WT, dnRAG1, Eμ-TCL1 and DTG mice. (Left Panel) Overlay of CD1d expression on CD19+CD5− (WT) or CD19+CD5+ (WT, dnRAG1, Eμ-TCL1 and DTG) B cells from representative animals. (Right panel) Mean fluorescence intensity of CD1d staining in the gated populations in the left panel (n = 4–6 animals/genotype). Statistically significant differences (p < 0.05) were only detected in comparisons between dnRAG1 mice and the other mouse genotypes (a, vs WT mice; b, vs Eμ-TCL1 mice; c, vs DTG mice)

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BMC Immunology

ISSN: 1471-2172

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