Fig. 4

RAIN networks of potential miR-130a targets (with miR-130a association probabilities in the top 20 %) and differentially regulated proteins identified for the 32Dcl3 miR-130a clone following miR-130a inhibition. Only proteins with STRING association probabilities above 0.7 and interactions with significantly regulated proteins are included. Square: predicted target (= top 20 %). Oval: not predicted. Bold outline: in dataset and significant. Thin outline: in dataset but not significant. No outline and blue: not in dataset. Red: up-regulated >0.3 (log2 ratio) upon miR-130a inhibition. Green: down-regulated < −0.3 (log2 ratio) upon miR-130a inhibition. Grey: regulated less than 0.3 (log2 ratio). These fold changes are included in the network to also indicate the observed direction of strongly predicted targets quantified but not significantly regulated within the data set