Skip to main content

Table 1 General characteristics of the study participants

From: Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

 

Controls

HIV+

 

N = 10

N = 43

 

Median or n

IQR or %

Median or n

IQR or %

Demography and lifestyle

    

 Age (years)

48.1

41.9–62.3

49.8

43.3–55.2

 Smoking

0

0 %

14*

32.6 %

Body composition

    

 Lipodystrophy

—

—

14

32.6 %

 BMI (kg/m2)

25.4

24.7–28.6

25.1

23.0–27.7

 FMI (kg/m2)

5.2

4.6–7.5

4.6

3.4–6.4

 VAT (cm2)

111.6

93.5–157.5

150.8

115.0–212.2

  lLMI (kg/m2)

6.4

6.2–6.8

6.1

5.7–6.6

Metabolic parameters

    

 HOMA-IR

0.5

0.5–1.3

1.2*

0.6–2.4

 Metabolic syndrome

1

10 %

20

46.5 %

Biomarkers of inflammation

    

 IL-6 (pg/mL)

1.1

0.7–2.4

1.6

1.1–2.6

 suPAR (ng/mL)

1.8

1.5–2.1

2.2*

1.8–2.8

HIV- and immune-related parameters

    

 HIV duration (years)

—

—

14

6.6–21.0

 ART duration (years)

—

—

10.2

4.4–14.8

 Current PI treatment

—

—

13

30.2 %

 Current NRTI treatment

—

—

43

100 %

 Current NNRTI treatment

—

—

28

65.1 %

 Other current ART

—

—

4

9.30 %

 HIV RNA ≤20 copies/mL

—

—

39

90.7 %

 CD4+ T cell count (cells/μL)

729

674–880

580

403–820

 CD8+ T cell count (cells/μL)

373

281–440

828***

618–1120

 CD4:CD8 ratio

2.0

1.8–3.0

0.7***

0.5–1.0

  1. Continuous measures are listed as: median and interquartile range. Categorical variables are listed as: number of participants and percentage
  2. Abbreviations: BMI body mass index, ART antiretroviral therapy, FMI fat mass index, HOMA-IR homeostatic model assessment of insulin resistance, IL-6 interleukin-6, IQR interquartile range, lLMI leg lean mass index, NRTI nucleoside reverse-transcriptase inhibitors, NNRTI non-nucleoside reverse-transcriptase inhibitor, PI protease inhibitor, suPAR soluble urokinase plasminogen activator receptor, VAT visceral adipose tissue
  3. The bold values are statistically significant at * P < 0.05, ** P < 0.01, *** P < 0.001