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Table 2 Unadjusted and adjusted associations between KLRG1+CD8+ T cell groups and ageing parameters in HIV+

From: Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

  Maturation - CD27/CD45RA Differentiation - CD27/CD28
  % KLRG1+ TN a % KLRG1+ Memorya % KLRG1+CD28+a % KLRG1+CD28
  Estimate 95 % CI Estimate 95 % CI Estimate 95 % CI Estimate 95 % CI
Age (per year extra) −0.84 −4.32 – 2.77 1.12 −2.19 – 4.53 1.54 −1.73 – 4.93 0.05 −0.81 – 0.92
−0.16 −4.22 – 4.07 0.32 −3.53 – 4.32 0.49 −3.16 – 4.28 −0.24 −1.24 – 0.76
IL-6 (per extra pg/mL) −0.24 −17.69 – 20.92 −8.07 −22.94 – 9.68 3.27 −13.80 – 23.71 −0.84 −5.53 – 3.85
−2.98 −21.71 – 20.23 −7.08 −23.90 – 13.47 9.10 −9.84 – 32.03 0.11 −5.16 – 5.38
suPAR (per extra ng/mL) −13.66 −40.90 – 26.14 −21.72 −44.54 – 10.50 −18.83 −42.12 – 13.82 −5.62 −14.38 – 3.14
−15.63 −43.65 – 26.30 −20.25 −45.09 – 15.84 −17.17 −41.55 – 17.38 −4.90 −14.36 – 4.56
HOMA-IR (per extra 1-unit) 16.39 −17.36 – 63.93 18.91 −13.42 – 63.30 27.27 −6.34 – 72.93 6.02 −1.96 – 14.01
35.74 −9.23 – 103.01 22.91 −16.71 – 81.38 27.45 −10.90 – 82.29 6.98 −2.65 – 16.16
Metabolic syndrome (vs. no metabolic syndrome) 23.25 −34.76 – 132.83 46.43 −17.97 – 161.42 70.88 −1.41 – 196.17 14.31* 0.10 – 28.53
48.94 −29.02 – 212.55 41.31 −29.88 – 184.78 61.77 −15.73 – 210.55 17.59* 0.73 – 34.45
VAT (per extra cm2) −0.10 −0.55 – 0.35 0.28 −0.12 – 0.70 0.45* 0.06 – 0.84 0.10 −0.00 – 0.20
0.14 −0.54 – 0.82 0.28 −0.34 – 0.90 0.62* 0.07 – 1.16 0.16* 0.01 – 0.31
lLMI (per extra kg/m2) 66.47* 10.22 – 151.43 36.88 −5.52 – 98.30 22.54 −20.06 – 87.86 7.92 −2.88 – 18.71
59.19 −0.55 – 154.80 45.52 −1.35 – 114.65 33.83 −13.85 – 107.92 10.09 −1.22 – 21.39
  1. Adjusted analyses are in grey. Age was adjusted for HIV-duration, ART-duration, and current ART; IL-6, suPAR, HOMA-IR, metabolic syndrome, VAT, and lLMI were adjusted for age, HIV-duration, ART-duration, and current ART
  2. Abbreviations: HOMA-IR homeostatic model assessment of insulin resistance, IL-6 interleukin-6, KLRG1 killer cell lectin-like receptor G1, lLMI leg lean mass index, suPAR soluble urokinase plasminogen activator receptor, T N naïve T cell, VAT visceral adipose tissue
  3. The bold values are statistically significant at * P < 0.05
  4. aParameters were transformed using log2(x). Estimates and confidence intervals are back transformed using (2β-1) × 100, and shown as percent change in the outcome per unit increase of the covariate