|
Maturation - CD27/CD45RA
|
Differentiation - CD27/CD28
|
---|
|
% KLRG1+ TN
a
|
% KLRG1+ Memorya
|
% KLRG1+CD28+a
|
% KLRG1+CD28−
|
---|
|
Estimate
|
95 % CI
|
Estimate
|
95 % CI
|
Estimate
|
95 % CI
|
Estimate
|
95 % CI
|
---|
Age (per year extra)
|
−0.84
|
−4.32 – 2.77
|
1.12
|
−2.19 – 4.53
|
1.54
|
−1.73 – 4.93
|
0.05
|
−0.81 – 0.92
|
−0.16
|
−4.22 – 4.07
|
0.32
|
−3.53 – 4.32
|
0.49
|
−3.16 – 4.28
|
−0.24
|
−1.24 – 0.76
|
IL-6 (per extra pg/mL)
|
−0.24
|
−17.69 – 20.92
|
−8.07
|
−22.94 – 9.68
|
3.27
|
−13.80 – 23.71
|
−0.84
|
−5.53 – 3.85
|
−2.98
|
−21.71 – 20.23
|
−7.08
|
−23.90 – 13.47
|
9.10
|
−9.84 – 32.03
|
0.11
|
−5.16 – 5.38
|
suPAR (per extra ng/mL)
|
−13.66
|
−40.90 – 26.14
|
−21.72
|
−44.54 – 10.50
|
−18.83
|
−42.12 – 13.82
|
−5.62
|
−14.38 – 3.14
|
−15.63
|
−43.65 – 26.30
|
−20.25
|
−45.09 – 15.84
|
−17.17
|
−41.55 – 17.38
|
−4.90
|
−14.36 – 4.56
|
HOMA-IR (per extra 1-unit)
|
16.39
|
−17.36 – 63.93
|
18.91
|
−13.42 – 63.30
|
27.27
|
−6.34 – 72.93
|
6.02
|
−1.96 – 14.01
|
35.74
|
−9.23 – 103.01
|
22.91
|
−16.71 – 81.38
|
27.45
|
−10.90 – 82.29
|
6.98
|
−2.65 – 16.16
|
Metabolic syndrome (vs. no metabolic syndrome)
|
23.25
|
−34.76 – 132.83
|
46.43
|
−17.97 – 161.42
|
70.88
|
−1.41 – 196.17
|
14.31*
|
0.10 – 28.53
|
48.94
|
−29.02 – 212.55
|
41.31
|
−29.88 – 184.78
|
61.77
|
−15.73 – 210.55
|
17.59*
|
0.73 – 34.45
|
VAT (per extra cm2)
|
−0.10
|
−0.55 – 0.35
|
0.28
|
−0.12 – 0.70
|
0.45*
|
0.06 – 0.84
|
0.10
|
−0.00 – 0.20
|
0.14
|
−0.54 – 0.82
|
0.28
|
−0.34 – 0.90
|
0.62*
|
0.07 – 1.16
|
0.16*
|
0.01 – 0.31
|
lLMI (per extra kg/m2)
|
66.47*
|
10.22 – 151.43
|
36.88
|
−5.52 – 98.30
|
22.54
|
−20.06 – 87.86
|
7.92
|
−2.88 – 18.71
|
59.19
|
−0.55 – 154.80
|
45.52
|
−1.35 – 114.65
|
33.83
|
−13.85 – 107.92
|
10.09
|
−1.22 – 21.39
|
- Adjusted analyses are in grey. Age was adjusted for HIV-duration, ART-duration, and current ART; IL-6, suPAR, HOMA-IR, metabolic syndrome, VAT, and lLMI were adjusted for age, HIV-duration, ART-duration, and current ART
- Abbreviations: HOMA-IR homeostatic model assessment of insulin resistance, IL-6 interleukin-6, KLRG1 killer cell lectin-like receptor G1, lLMI leg lean mass index, suPAR soluble urokinase plasminogen activator receptor, T
N
naïve T cell, VAT visceral adipose tissue
- The bold values are statistically significant at *
P < 0.05
-
aParameters were transformed using log2(x). Estimates and confidence intervals are back transformed using (2β-1) × 100, and shown as percent change in the outcome per unit increase of the covariate