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Table 2 Unadjusted and adjusted associations between KLRG1+CD8+ T cell groups and ageing parameters in HIV+

From: Immunosenescence of the CD8+ T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls

 

Maturation - CD27/CD45RA

Differentiation - CD27/CD28

 

% KLRG1+ TN a

% KLRG1+ Memorya

% KLRG1+CD28+a

% KLRG1+CD28−

 

Estimate

95 % CI

Estimate

95 % CI

Estimate

95 % CI

Estimate

95 % CI

Age (per year extra)

−0.84

−4.32 – 2.77

1.12

−2.19 – 4.53

1.54

−1.73 – 4.93

0.05

−0.81 – 0.92

−0.16

−4.22 – 4.07

0.32

−3.53 – 4.32

0.49

−3.16 – 4.28

−0.24

−1.24 – 0.76

IL-6 (per extra pg/mL)

−0.24

−17.69 – 20.92

−8.07

−22.94 – 9.68

3.27

−13.80 – 23.71

−0.84

−5.53 – 3.85

−2.98

−21.71 – 20.23

−7.08

−23.90 – 13.47

9.10

−9.84 – 32.03

0.11

−5.16 – 5.38

suPAR (per extra ng/mL)

−13.66

−40.90 – 26.14

−21.72

−44.54 – 10.50

−18.83

−42.12 – 13.82

−5.62

−14.38 – 3.14

−15.63

−43.65 – 26.30

−20.25

−45.09 – 15.84

−17.17

−41.55 – 17.38

−4.90

−14.36 – 4.56

HOMA-IR (per extra 1-unit)

16.39

−17.36 – 63.93

18.91

−13.42 – 63.30

27.27

−6.34 – 72.93

6.02

−1.96 – 14.01

35.74

−9.23 – 103.01

22.91

−16.71 – 81.38

27.45

−10.90 – 82.29

6.98

−2.65 – 16.16

Metabolic syndrome (vs. no metabolic syndrome)

23.25

−34.76 – 132.83

46.43

−17.97 – 161.42

70.88

−1.41 – 196.17

14.31*

0.10 – 28.53

48.94

−29.02 – 212.55

41.31

−29.88 – 184.78

61.77

−15.73 – 210.55

17.59*

0.73 – 34.45

VAT (per extra cm2)

−0.10

−0.55 – 0.35

0.28

−0.12 – 0.70

0.45*

0.06 – 0.84

0.10

−0.00 – 0.20

0.14

−0.54 – 0.82

0.28

−0.34 – 0.90

0.62*

0.07 – 1.16

0.16*

0.01 – 0.31

lLMI (per extra kg/m2)

66.47*

10.22 – 151.43

36.88

−5.52 – 98.30

22.54

−20.06 – 87.86

7.92

−2.88 – 18.71

59.19

−0.55 – 154.80

45.52

−1.35 – 114.65

33.83

−13.85 – 107.92

10.09

−1.22 – 21.39

  1. Adjusted analyses are in grey. Age was adjusted for HIV-duration, ART-duration, and current ART; IL-6, suPAR, HOMA-IR, metabolic syndrome, VAT, and lLMI were adjusted for age, HIV-duration, ART-duration, and current ART
  2. Abbreviations: HOMA-IR homeostatic model assessment of insulin resistance, IL-6 interleukin-6, KLRG1 killer cell lectin-like receptor G1, lLMI leg lean mass index, suPAR soluble urokinase plasminogen activator receptor, T N naïve T cell, VAT visceral adipose tissue
  3. The bold values are statistically significant at * P < 0.05
  4. aParameters were transformed using log2(x). Estimates and confidence intervals are back transformed using (2β-1) × 100, and shown as percent change in the outcome per unit increase of the covariate