Fig. 5

Correlations between the percentage of CD4⁺ T cells producing IL-17 in peripheral blood and eosinophil count in the colonic submucosa (a); the crypt-to-crypt distance (b); the basement membrane-to-crypt distance (c), the ICAM-1 level (d); the VCAM-1 level (e); and the VEGF level (f) in the sera of patients with eosinophilic granulomatosis with polyangiitis (EGPA). Closed circles: mucous membrane of colon biopsied at onset of EGPA. Open circles: mucous membrane of colon biopsied in remission after treatment with corticosteroids with or without immunosuppressants. Correlation coefficients (r values) and P values were calculated by using Spearman’s rank correlation test