Table 2 Comparison of peripheral blood biomarkers or pathological findings in the large intestinal mucosa between patients with eosinophilic granulomatosis with polyangiitis (EGPA) and those with chronic eosinophilic pneumonia (CEP)

WBC (/mL) in blood, mean ± 1 SD

15,150 ± 9,062^b,a

8,655 ± 2,542

< 0.01^a

9,906 ± 4,637

6,928 ± 2,086

< 0.01^b

Blood eosinophils (/mL), mean ± 1 SD

7,356 ± 6,293^b,**

142.9 ± 132.7

< 0.01^a

3,390 ± 3,575

585.0 ± 443.0

< 0.01^a

log IgE RIST in serum

2.910 ± 0.495

0.754 ± 0.259

< 0.01^a

2.647 ± 0.505

0.921 ± 0.445

< 0.01^a

MPO-ANCA (%)

41.2^c,*

0

< 0.05^c,*

0

0

NS^c

PR3-ANCA (%)

0

0

NS^c

0

0

NS^c

ICAM-1 level in serum (ng/mL)

531.5 ± 136.4^b,*

392.2 ± 128.3

< 0.01^a

372.0 ± 259.6

343.4 ± 37.3

NS^a

VCAM-1 level in serum (ng/mL)

2633.6 ± 4102.7

756.5 ± 563.9

< 0.05^a

651.6 ± 132.0

680.2 ± 415.1

NS^a

VEGF level in serum (pg/mL)

231.9 ± 169.4

388.7 ± 265.3

< 0.05^a

192.1 ± 99.1

104.8 ± 111.0

NS^a

Percentage of CD4⁺ T cells producing IL-17 (%)

8.9 ± 5.2^b,**

0.7 ± 1.8

< 0.01

2.2 ± 2.7

1.0 ± 1.8

NS^a

Necrotizing vasculitis (yes/no)

0/17

0/17

NS^c

0/12

N.D

NS^c

Granuloma (yes/no)

0/17

0/17

NS^c

0/12

N.D

NS^c

The number of eosinophils in submucosa (/mm²)

113.0 ± 46.6^b,*

29.5 ± 18.8

< 0.01^a

81.9 ± 49.3

N.D

Interval between basement membrane and crypt (/mm)

7.7 ± 1.3^b,**

5.8 ± 1.2

< 0.01^a

5.4 ± 1.9

N.D

Interval between crypt and crypt (/mm)

5.5 ± 1.0^b,**

3.7 ± 1.7

< 0.01^a

2.8 ± 1.0

N.D