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Table 2 Comparison of peripheral blood biomarkers or pathological findings in the large intestinal mucosa between patients with eosinophilic granulomatosis with polyangiitis (EGPA) and those with chronic eosinophilic pneumonia (CEP)

From: Th17 cells reflect colon submucosal pathologic changes in active eosinophilic granulomatosis with polyangiitis

  EGPA patients (n = 17)   Comparison between EGPA patients with at onset and at remission CEP patients (n = 12)   Comparison between CEP patients with at onset and after an improvement
  At onset At remission P At onset After an improvement P
Peripheral blood
WBC (/mL) in blood, mean ± 1 SD 15,150 ± 9,062b,a 8,655 ± 2,542 < 0.01a 9,906 ± 4,637 6,928 ± 2,086 < 0.01b
Blood eosinophils (/mL), mean ± 1 SD 7,356 ± 6,293b,** 142.9 ± 132.7 < 0.01a 3,390 ± 3,575 585.0 ± 443.0 < 0.01a
log IgE RIST in serum 2.910 ± 0.495 0.754 ± 0.259 < 0.01a 2.647 ± 0.505 0.921 ± 0.445 < 0.01a
MPO-ANCA (%) 41.2c,* 0 < 0.05c,* 0 0 NSc
PR3-ANCA (%) 0 0 NSc 0 0 NSc
ICAM-1 level in serum (ng/mL) 531.5 ± 136.4b,* 392.2 ± 128.3 < 0.01a 372.0 ± 259.6 343.4 ± 37.3 NSa
VCAM-1 level in serum (ng/mL) 2633.6 ± 4102.7 756.5 ± 563.9 < 0.05a 651.6 ± 132.0 680.2 ± 415.1 NSa
VEGF level in serum (pg/mL) 231.9 ± 169.4 388.7 ± 265.3 < 0.05a 192.1 ± 99.1 104.8 ± 111.0 NSa
Percentage of CD4+ T cells producing IL-17 (%) 8.9 ± 5.2b,** 0.7 ± 1.8 < 0.01 2.2 ± 2.7 1.0 ± 1.8 NSa
Pathological findings in colon
Necrotizing vasculitis (yes/no) 0/17 0/17 NSc 0/12 N.D NSc
Granuloma (yes/no) 0/17 0/17 NSc 0/12 N.D NSc
The number of eosinophils in submucosa (/mm2) 113.0 ± 46.6b,* 29.5 ± 18.8 < 0.01a 81.9 ± 49.3 N.D  
Interval between basement membrane and crypt (/mm) 7.7 ± 1.3b,** 5.8 ± 1.2 < 0.01a 5.4 ± 1.9 N.D  
Interval between crypt and crypt (/mm) 5.5 ± 1.0b,** 3.7 ± 1.7 < 0.01a 2.8 ± 1.0 N.D  
  1. ANCA antineutrophil cytoplasmic antibodies, ICAM-1 intercellular adhesion molecule-1, MPO myeloperoxidase, NS not significant, PR3 proteinase 3, RIST radioimmunosorbent, VCAM-1 vascular cell adhesion molecule-1, VEGF vascular endothelial growth factor, WBCs white blood cells
  2. All values are expressed as means ± SD
  3. aStatistical comparisons performed with the Wilcoxon matched-pairs T-test
  4. bTwo-way ANOVA with repeated measures between groups
  5. cChi-squared testing revealed no significant differences between groups
  6. Values of P < 0.05 were considered statistically significant
  7. *EGPA at onset vs. CEP at onset, P < 0.05
  8. **EGPA at onset vs. CEP at onset, P < 0.01