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Table 3 Best Stepwise models selected for each set from cytokines stable across HC groups of age ≤50 years

From: Illness progression in chronic fatigue syndrome: a shifting immune baseline

Subject sub-group Classification model   
  Training selection Training selection  
(a) Training set: Age < =18 years IL-1α, 6, 8 IL-1α, 6, 8  
 Correct rate 0.88 0.88  
 Error rate 0.12 0.12  
 Sensitivity 0.89 0.89  
 Specificity 0.88 0.88  
 Positive predictive value 0.84 0.84  
 Negative predictive value 0.91 0.91  
  Training selection Test set Parameters tuned
(b) Training set: 18 < Age < = 50 years IL-1α, 15 IL-1α, 6, 8 IL-1α, 6, 8
 Correct rate 0.72 0.37 0.77
 Error rate 0.28 0.63 0.23
 Sensitivity 0.73 0.09 0.77
 Specificity 0.71 0.67 0.76
 Positive predictive value 0.73 0.22 0.77
 Negative predictive value 0.71 0.41 0.76
(c) Training set: Age > 50 years a IL-6, 8, 15, TNFα IL-1α, 6, 8 IL-1α, 6, 8
 Correct rate 0.84 0.48 0.75
 Error rate 0.16 0.52 0.25
 Sensitivity 0.86 0.18 0.75
 Specificity 0.82 0.79 0.75
 Positive predictive value 0.83 0.45 0.75
 Negative predictive value 0.85 0.49 0.75
  1. a n = 28 of 47 HC to match CFS/ME age and BMI