BMC Immunology

Table 3 Best Stepwise models selected for each set from cytokines stable across HC groups of age ≤50 years

From: Illness progression in chronic fatigue syndrome: a shifting immune baseline

Subject sub-group	Classification model
	Training selection	Training selection
(a) Training set: Age < =18 years	IL-1α, 6, 8	IL-1α, 6, 8
Correct rate	0.88	0.88
Error rate	0.12	0.12
Sensitivity	0.89	0.89
Specificity	0.88	0.88
Positive predictive value	0.84	0.84
Negative predictive value	0.91	0.91
	Training selection	Test set	Parameters tuned
(b) Training set: 18 < Age < = 50 years	IL-1α, 15	IL-1α, 6, 8	IL-1α, 6, 8
Correct rate	0.72	0.37	0.77
Error rate	0.28	0.63	0.23
Sensitivity	0.73	0.09	0.77
Specificity	0.71	0.67	0.76
Positive predictive value	0.73	0.22	0.77
Negative predictive value	0.71	0.41	0.76
(c) Training set: Age > 50 years ^a	IL-6, 8, 15, TNFα	IL-1α, 6, 8	IL-1α, 6, 8
Correct rate	0.84	0.48	0.75
Error rate	0.16	0.52	0.25
Sensitivity	0.86	0.18	0.75
Specificity	0.82	0.79	0.75
Positive predictive value	0.83	0.45	0.75
Negative predictive value	0.85	0.49	0.75

^a n = 28 of 47 HC to match CFS/ME age and BMI

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ISSN: 1471-2172

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