TY - JOUR AU - Najera, Julia A. AU - Bustamante, Eduardo A. AU - Bortell, Nikki AU - Morsey, Brenda AU - Fox, Howard S. AU - Ravasi, Timothy AU - Marcondes, Maria Cecilia Garibaldi PY - 2016 DA - 2016/04/23 TI - Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets JO - BMC Immunology SP - 7 VL - 17 IS - 1 AB - Methamphetamine (Meth) abuse is a major health problem linked to the aggravation of HIV- associated complications, especially within the Central Nervous System (CNS). Within the CNS, Meth has the ability to modify the activity/function of innate immune cells and increase brain viral loads. Here, we examined changes in the gene expression profile of neuron-free microglial cell preparations isolated from the brain of macaques infected with the Simian Immunodeficiency Virus (SIV), a model of neuroAIDS, and exposed to Meth. We aimed to identify molecular patterns triggered by Meth that could explain the detection of higher brain viral loads and the development of a pro-inflammatory CNS environment in the brain of infected drug abusers. SN - 1471-2172 UR - https://doi.org/10.1186/s12865-016-0145-0 DO - 10.1186/s12865-016-0145-0 ID - Najera2016 ER -