Fig. 3

Highest scoring significant modules associated to immune functions in microglia from Meth-treated macaques. Comparisons between Meth and controls (a, b, c), SIV and controls (d, e, f), and SIV/Meth and SIV (g, h, i) were performed using Cytoscape interface, and Biogrid plugin. Data was filtered based on fold-change above 1.5-fold and p value <0.05. Clustered gene nodes were selected to present at least two upregulated genes in Meth compared to controls, and to have a described role affecting CNS immune functions and viral load. These filtered nodes were related to extrinsic apoptotic pathways (a, d, g), T-cell receptor (TCR) signaling (b, e, h), and macrophage and microglia activation and chemotaxis (c, f, i). Red color intensity signifies upregulation levels, and green signifies down-regulation. Shapes indicate significance, being squares p < 0.05 and circles >0.05