Table 1 Functional annotation chart for microglia gene pathways that were significantly up-regulated by Meth in microglia, as compared to controls. Number of genes, p-value and Benjamini value are presented. Complete data set is presented in Additional file 1: Table S1
Category | Term | Count | P-value | Benjamini |
|---|---|---|---|---|
KEGG_PATHWAY | Cytokine-cytokine receptor interaction | 24 | 9.00E-07 | 1.30E-04 |
GOTERM_BP_FAT | Immune response | 18 | 1.90E-03 | 2.50E-01 |
GOTERM_CC_FAT | Extracellular region part | 15 | 1.60E-02 | 6.30E-01 |
GOTERM_MF_FAT | Cytokine activity | 14 | 1.80E-03 | 1.90E-01 |
GOTERM_CC_FAT | Extracellular space | 14 | 2.10E-02 | 4.90E-01 |
KEGG_PATHWAY | Natural killer cell mediated cytotoxicity | 13 | 8.10E-04 | 5.50E-02 |
KEGG_PATHWAY | Chemokine signaling pathway | 13 | 3.20E-02 | 2.90E-01 |
GOTERM_BP_FAT | Defense response | 12 | 1.40E-02 | 4.60E-01 |
KEGG_PATHWAY | Jak-STAT signaling pathway | 12 | 1.80E-02 | 2.00E-01 |
KEGG_PATHWAY | T cell receptor signaling pathway | 10 | 1.50E-02 | 2.10E-01 |
KEGG_PATHWAY | Hematopoietic cell lineage | 9 | 1.10E-02 | 1.80E-01 |
KEGG_PATHWAY | Toll-like receptor signaling pathway | 9 | 2.30E-02 | 2.40E-01 |
KEGG_PATHWAY | NOD-like receptor signaling pathway | 8 | 5.50E-03 | 1.40E-01 |
KEGG_PATHWAY | Allograft rejection | 8 | 7.40E-03 | 1.60E-01 |
GOTERM_BP_FAT | Response to wounding | 8 | 1.30E-02 | 5.10E-01 |
KEGG_PATHWAY | Fc epsilon RI signaling pathway | 8 | 1.70E-02 | 2.10E-01 |
KEGG_PATHWAY | Asthma | 7 | 2.00E-03 | 6.80E-02 |
GOTERM_BP_FAT | Inflammatory response | 7 | 7.90E-03 | 3.90E-01 |
KEGG_PATHWAY | Cytosolic DNA-sensing pathway | 7 | 8.20E-03 | 1.50E-01 |
KEGG_PATHWAY | Autoimmune thyroid disease | 7 | 5.70E-02 | 4.20E-01 |
GOTERM_BP_FAT | Chemotaxis | 6 | 1.40E-02 | 4.20E-01 |
GOTERM_MF_FAT | Cytokine binding | 6 | 3.40E-02 | 8.60E-01 |
GOTERM_BP_FAT | Locomotors behavior | 6 | 3.40E-02 | 7.10E-01 |
KEGG_PATHWAY | Graft-versus-host disease | 6 | 4.30E-02 | 3.60E-01 |
INTERPRO | Immunoglobulin | 6 | 4.50E-02 | 9.00E-01 |
KEGG_PATHWAY | Type I diabetes mellitus | 6 | 6.90E-02 | 4.70E-01 |
GOTERM_BP_FAT | Behavior | 6 | 7.90E-02 | 9.20E-01 |
GOTERM_BP_FAT | Cell migration | 5 | 1.80E-03 | 4.30E-01 |
GOTERM_BP_FAT | Cell motility | 5 | 3.30E-03 | 2.90E-01 |
INTERPRO | Small chemokine, C-C group, conserved site | 5 | 5.50E-02 | 8.80E-01 |
GOTERM_BP_FAT | Leukocyte migration | 4 | 6.40E-03 | 4.00E-01 |
INTERPRO | Chemokine receptor | 4 | 6.40E-02 | 8.70E-01 |
GOTERM_MF_FAT | C-C chemokine receptor activity | 4 | 7.20E-02 | 9.40E-01 |
GOTERM_MF_FAT | C-C chemokine binding | 4 | 7.20E-02 | 9.40E-01 |
GOTERM_MF_FAT | Chemokine receptor activity | 4 | 9.50E-02 | 9.40E-01 |