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Table 6 Genes significantly changed in connection with the upregulation of CCR5 in Meth compared to control microglia

From: Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets

CanonicalName

Meth/Ctr FC

Meth/Ctr pvalue

Name

CCL5

3.664732509

0.0008

Chemokine (C-C motif) ligand 5

RALGPS2

2.894990056

0.0206

Ral GEF with PH domain and SH3 binding motif 2

CCL3

2.632055343

0.0160

Chemokine (C-C motif) ligand 3

IL8

2.330578386

0.0152

Interleukin 8

KIF23

2.32350165

0.0090

Kinesin family member 23

PRPF19

2.277978004

0.0486

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

CCR5

2.244743162

0.0149

Chemokine (C-C motif) receptor 5

IL16

2.22856945

0.0025

Interleukin 16 (lymphocyte chemoattractant factor)

TGFB1

2.094232364

0.0181

Transforming growth factor, beta 1

PTK2B

2.075586714

0.0239

PTK2B protein tyrosine kinase 2 beta

CXCR4

2.290261762

0.0151

Chemokine (C-X-C motif) receptor 4

CCL2

1.976229643

0.0052

Chemokine (C-C motif) ligand 2

CCR1

1.944997932

0.0463

Chemokine (C-C motif) receptor 1

FGFR2

1.803077177

0.0075

Fibroblast growth factor receptor-2

PIN1

1.76086754

0.0429

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

VDAC1

1.745554071

0.0238

Voltage-dependent anion channel 1; similar to voltage-dependent anion channel 1

SIRPA

1.655090623

0.0180

Signal-regulatory protein alpha

PTPN6

1.651490977

0.0182

Protein tyrosine phosphatase, non-receptor type 6

AP2A1

1.648603535

0.0347

Adaptor-related protein complex 2, alpha 1 subunit

CRTC2

1.612923593

0.0216

CREB regulated transcription coactivator 2

ITGB5

1.580576538

0.0274

Integrin, beta 5

AR

1.575448506

0.0400

Androgen receptor

TNFAIP3

1.563086606

0.0044

Tumor necrosis factor, alpha-induced protein 3

BTRC

1.552901893

0.0263

Beta-transducin repeat containing

C5orf25

1.542952379

0.0097

Chromosome 5 open reading frame 25

NAGPA

1.524456014

0.0027

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

SDC4

1.523650476

0.0487

Syndecan 4

STAT6

1.482833897

0.0044

Signal transducer and activator of transcription 6

  1. A network that includes significantly upregulated first and second neighbors of CCR5, which appears in bold, was generated. Values represent fold change in Meth versus Control microglia and p value
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BMC Immunology

ISSN: 1471-2172

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