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Fig. 1 | BMC Immunology

Fig. 1

From: Applied immuno-epidemiological research: an approach for integrating existing knowledge into the statistical analysis of multiple immune markers

Fig. 1

Conceptual model: The figure visualizes current immunological concepts underlying atopic diseases and allergy. First, immuno-stimulating factors, e.g. infections or exposure to dust mite excretion or to helminths exert differential effects on Th1-, Th2 or TReg responses. In concert these mechanisms are presumed to affect the Th1/Th2 balance considered to be a major determinant for regulation of specific IgE that is a predictor for a positive skin pricktest (SPT). Further downstream, the model assumes that T-Reg modifies the effect of Th1/Th2 balance on the regulation of specific IgE antibodies as well as the effect of specific IgE on positivity of skin pricktest (SPT)

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