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Table 2 Summary of bivariate association analyses between each culture condition for each cytokine using data collected from 818 children in SCAALA Salvador

From: Applied immuno-epidemiological research: an approach for integrating existing knowledge into the statistical analysis of multiple immune markers

Cytokine

Measure

ASC

BLOM

DERM

MITO

IFN-γ

BLOM

γ = 0.21,

-

-

-

P = 0.144

 

DERM

γ = 0.77***,

γ = 0.73**,

-

-

P = <0.001

P = <0.001

 

MITO

γ = -0.24,

γ = 0.26*,

γ = 0.09,

-

P = 0.667

P = 0.016

P = 0.653

 

NC

γ = 0.29*,

γ = 0.05,

γ = 0.11,

γ = -0.84***,

P = 0.242

P = 0.593

P = 0.412

P = <0.001

IL-5

BLOM

γ = -0.05,

-

-

-

P = 0.585

 

DERM

γ = 0.35*,

γ = 0.94***,

-

-

P = 0.057

P = <0.001

 

MITO

γ = 0.26*,

γ = -0.21,

γ = 0.19,

-

P = 0.047

P = 0.234

P = 0.568

 

NC

γ = 0.38*,

γ = 0.61**,

γ = 0.76***,

γ = 0.09,

P = <0.001

P = <0.001

P = <0.001

P = 0.405

IL-13

BLOM

γ = 0.83***,

-

-

-

P = <0.001

 

DERM

γ = 0.83***,

γ = 0.85***,

-

-

P = <0.001

P = <0.001

 

MITO

γ = 0.47*,

γ = 0.28*,

γ = 0.52**,

-

P = <0.001

P = 0.016

P = <0.001

 

NC

γ = 0.43*,

γ = 0.70**,

γ = 0.45*,

γ = 0.09,

P = <0.001

P = <0.001

P = <0.001

P = 0.005

IL-10

BLOM

γ = 0.28*,

-

-

-

P = 0.510

 

DERM

γ = 0.69**,

γ = 0.35*,

-

-

P = <0.001

P = <0.001

 

MITO

γ = 0.26*,

γ = 0.93***,

γ = 0.43*,

-

P = 0.326

P = <0.001

P = <0.001

 

NC

γ = -0.03,

γ = -0.95***,

γ = -0.35*,

γ = -0.96***,

P = 0.468

P = <0.001

P = 0.008

P = <0.001

  1. ASC: response in cell culture stimulated by A. lumbricoides, BLOM: response in cell culture stimulated by B. tropicalis, DERM: response in cell culture stimulated by D. pteronyssinus, MITO: response in cell culture stimulated by pokeweed mitogen, NC: response in nonstimulated cell culture; γ: Goodman and Kruskal’s γ, P: P-value of chi-square test of independence; Strength of association: * … weak (0.25 < |γ| < =0.5)
  2. ** … moderate (0.50 < |γ| < =0.75); *** … strong (0.75 < |γ| < =1); Significant estimates (P<0.05) are shown in bold