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Fig. 2 | BMC Immunology

Fig. 2

From: Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins

Fig. 2

Enrichment of putative PDZ ligand motifs in the cytoplasmic domain of mouse MHCI proteins. a Frequency of the class 1 PDZ ligand consensus motif [X (S/T) X (V/L)] [51] in the cytoplasmic domain (“CYTO”), extracellular domain (“EXTRA”) or scrambled full sequence (“SCRAM”) of 20 mouse MHCI and MHCI-like proteins (see Methods for list), represented as motifs per 100 amino acids. PDZ ligand motifs are enriched in the cytoplasmic domain. Inset, frequency of PDZ ligand motifs in five viral MHCI mimics (UL-18, UL-37, UL-142, M144, and M153), which are likely to be under different selective pressures than host MHCI. Axis labels in insets match those in main graph and are omitted for clarity. b Frequency of inverted, non-functional class 1 PDZ ligand motifs [(V/L) X (S/T) X] in the same MHCI amino acid sequences. c PDZ ligand motifs in MHCI amino acid sequences, represented in relation to the number of inverted motifs in the same domain. Inset, same data from the five viral MHCI mimics used in (a). d Representation of four specific class 1 PDZ ligand consensus motifs (XSXV, XSXL, XTXV, XTXL) [51] in the extracellular (top) versus cytoplasmic (bottom) domains of 99 MHCI proteins from 21 species. Serine-containing motifs are significantly over-represented relative to threonine-containing motifs in the cytoplasmic domain. MHCI schematic, rcsb-pdb (http://pdb101.rcsb.org/motm/62). ef Representation of specific class 2 (ΦXΦ) and class 3 (X (D/E) X Φ) PDZ ligand motifs, respectively, where Φ = V/I/L/M/F/W/A/C. For a complete list of class 2 and class 3 ligands plotted and their frequencies, see Additional file 3: Figure S3. Color code is the same in both extracellular and cytoplasmic charts

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