Fig. 4
From: Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice
Human immune cell reconstitution in the liver of adult and pup-engrafted humanized mice comprised of T- and B-cells. Livers were isolated from humanized mice 9–28 weeks post transplantation and analyzed for mouse CD45 and human CD45, CD3, CD4, CD8, CD56, CD19, CD14 expression. Events were first analyzed for mouse and human CD45 expression. Representative flow plots displayed in (a) and graphically represented in (b). Based on human CD45 expression, livers were then analyzed for CD3, CD56, CD14, and CD19 expression. Representative flow plots shown in (c) and stratified by tissue in (d). Human CD3 cells were further examined for human CD4 and CD8 expression, shown in (e) and (f). n = 3; *p < 0.05