TY - JOUR AU - Barbosa-Lorenzi, Valéria Cintra AU - Cecilio, Nerry Tatiana AU - de Almeida Buranello, Patricia Andressa AU - Pranchevicius, Maria Cristina AU - Goldman, Maria Helena S. AU - Pereira-da-Silva, Gabriela AU - Roque-Barreira, Maria Cristina AU - Jamur, Maria Célia AU - Oliver, Constance PY - 2016 DA - 2016/07/04 TI - Recombinant ArtinM activates mast cells JO - BMC Immunology SP - 22 VL - 17 IS - 1 AB - Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed and lipid mediators, and the delayed release of cytokines. The native homotetrameric lectin ArtinM, a D-mannose binding lectin purified from Artocarpus heterophyllus seeds, is one of several lectins that are able to activate mast cells. Besides activating mast cells, ArtinM has been shown to affect several biological responses, including immunomodulation and acceleration of wound healing. Because of the potential pharmacological application of ArtinM, a recombinant ArtinM (rArtinM) was produced in Escherichia coli. The current study evaluated the ability of rArtinM to induce mast cell degranulation and activation. SN - 1471-2172 UR - https://doi.org/10.1186/s12865-016-0161-0 DO - 10.1186/s12865-016-0161-0 ID - Barbosa-Lorenzi2016 ER -