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Fig. 5 | BMC Immunology

Fig. 5

From: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

Fig. 5

Down regulated genes and network in congenic mice in comparison to that of BALB/c-/-type. a Down regulated genes in congenic mice. Probe/gene names are shown above the horizontal bar. Numbers on the left of the vertical bar is the score of differential expression. b Network of known arthritis relevant down regulated genes when congenics are compared to BALB/c-/-based on gene expression profiles in the spleen. The 13 nodes in the graph below show the selected traits. All nodes are displayed. The 4 edges between the nodes, filtered from the 78 total edges and drawn as curves, show Pearson correlation coefficients greater than 0.5 or less than -0.5. The graph’s canvas is 40.0 by 40.0 cm, and the node labels are drawn with a 16.0 point font, and the edge labels are drawn with a 16.0 point font. c Network of known arthritis relevant down regulated genes when congenics vs BALB/c-/-based on gene expression profiles in T help cells. The seven edges between the nodes, filtered from the 78 total edges and drawn as curves, show Pearson correlation coefficients greater than 0.5 or less than -0.5. d Network of known arthritis relevant down regulated genes when congenics are compared to BALB/c-/-based on gene expression profiles in T cell regulatory cells

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