Fig. 6

Eicosanoids are lower in BALF from cPLA₂α^−/− than cPLA₂α^+/+ mice during C. albicans infection. Levels of (a) cysteinyl leukotrienes, leukotriene C₄ (LTC₄), leukotriene D₄ (LTD₄) and leukotriene E₄ (LTE₄) and (b) cyclooxygenase metabolites thromboxane B₂ (TXB₂), prostaglandin E₂ (PGE₂), prostaglandin D₂ (PGD₂) and 6-keto prostaglandin F₁α (6-keto PGF₁α) were determined by mass spectrometry in BALF from cPLA₂α^−/− (KO) and cPLA₂α^+/+ (WT) mice instilled with saline or 10⁶ C. albicans (CA) for 24 h. Results are the mean ± SEM (n = 6 mice/group). Statistical differences were determined by the Mann Whitney protocol. *P < 0.05 compared to WT saline control; ^ϕ P < 0.05 compared to WT saline control, ^# P < 0.05 compared to KO saline control; **P < 0.05 compared to WT with CA