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Fig. 1 | BMC Immunology

Fig. 1

From: Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model

Fig. 1

Increased cycles of 5-FU inhibit tumor growth to a greater degree but do not improve OS compared with one-cycle treatment. a 5-FU treatment schedule for CT26-bearing mice. A total of 3 × 105 CT26 cells were injected s.c., and 5-FU (40 mg/kg) was administered at the indicated time point. b Tumor growth curve (data shown as the mean ± SEM) and c Kaplan-Meier survival analysis of mice treated with different cycles of 5-FU. Untreated tumor-bearing mice were used as a control (five to seven mice per group; results are representatives of at least two independent experiments). C1–C4, one to four cycles of 5-FU. Two-way ANOVA analysis for tumor volumes. Survival comparisons were calculated by the log-rank test. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, no significance

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