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Fig. 3 | BMC Immunology

Fig. 3

From: Lipoproteins attenuate TLR2 and TLR4 activation by bacteria and bacterial ligands with differences in affinity and kinetics

Fig. 3

Effect of HSdelip or HSdelip supplemented with VLDL, LDL or HDL on TNFα, B. breve or FSL-1 induced NFκB activity. HEK-TLR2-TLR6 cells were incubated with B. breve, FSL-1 or TNFα in the presence of HSdelip or HSdelip supplemented with a dose range of the lipoprotein fractions HDL, LDL or VLDL. TLR2/6 activity in response to B. breve (a) or FSL-1 (b) was dose-dependently inhibited by the different lipoprotein fractions. c None of the lipoprotein fractions inhibited the TNFα induced NFκB activity. Each value represents mean ± SD of triplicates. The experiment shown is representative of three separate experiments. *: p < 0.05 **:P < 0.01 ***:P < 0.001 determined by comparison with HSdelip

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