Table 3 Up-regulated genes in primary human gingival keratinocytes 24 h of infection with membrane fractions of P. gingivalis W83.
From: Porphyromonas gingivalis activates NFκB and MAPK pathways in human oral epithelial cells
Gene Symbol | Fold Regulation | Biological Function |
|---|---|---|
IRAK3 | 2.5 | TLR Signaling |
IRF5* | 14.3 | |
TRAF6 | 2.6 | |
HSP90AA1 | 2.7 | NLR Signaling |
NOD1 | 2.3 | |
NOD2 | 2.0 | |
XIAP | 2.4 | |
NAIP | 2.3 | |
BIRC3 | 2.2 | NLR Sign., Apoptosis |
IKBKB | 4.0 | NF-κB Pathway |
NFKB1 | 2.6 | |
NFKBIA | 2.4 | |
MAP2K4 | 2.6 | MAPK Signaling |
MAPK14 | 2.3 | |
MAPK8 | 2.0 | |
CRP | 3.8 | Inflammatory Response |
LBP | 2.6 | |
LY96 | 2.6 | |
AKT1 | 2.1 | Inflam. Resp., Apoptosis |
CCL3 | 3.2 | Chemokines |
CCL5 | 3.0 | |
CXCL2 | 2.1 | |
IL-12A | 2.2 | Cytokines |
IL-12B | 3.3 | |
IL18 | 2.7 | |
CASP1 | 2.1 | Apoptosis |
PYCARD | 3.5 | |
RIPK1 | 3.3 | |
BPI | 3.2 | Antimicrobial Peptides |
CAMP | 3.3 | |
MPO | 2.3 | |
SLPI | 3.6 | |
DMBT1 | 4.0 | Mucosal Immune Response |