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Table 3 B cell specific antigenic peptide epitopes short listed from a large set of initial population based on their antigenic score, model energy, average ASA (Accessible surface area) and average conservation

From: Insight into SNPs and epitopes of E protein of newly emerged genotype-I isolates of JEV from Midnapur, West Bengal, India

Start Position Linear Epitope Score Model Energy Av. ASA Av. H
325 ELTYSGSDGPCKIPIVSVAS 0.986 −23.71 22.8 0.01
372 VEMEPPFGDSYIVVGRGDKQ 0.977 −24.54 37.1 0.02
100 GWGKGCGLFGKGSIDTCAKF 0.956 −29.81 42.1 0.02
69 STVARCPTTGEAHNEKRADS 0.926 −12.95 59.3 0.01
395 HWHKAGSTLGKAFSTTLKGA 0.876 −23.38 97.2 0.02
121 CTSKAIGRMIQPENIKYEVG 0.854 −18.21 38.2 0.06
349 TPVGRLVTVNPFVATSSSNS 0.923 −20.55 39.9 0.04
48 IEASQLAEVRSYYYHASVTD 0.967 −32.65 31.4 0.06
  1. NACCESS program [44] was used to generate residue accessibility data. Then average accessibility was computed using side chain relative accessibility values. Variability was calculated using full length E protein sequences (total 50) and positional Shannon entropy (H) [17, 18] was computed for each homologous position. The Av. Variability is the average of all residues value. Average is made up to 404 residues as the model has 404 residues like template
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BMC Immunology

ISSN: 1471-2172

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