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Table 5 MHC class II specific top scored antigenic peptides along with associated alleles

From: Insight into SNPs and epitopes of E protein of newly emerged genotype-I isolates of JEV from Midnapur, West Bengal, India

Start Peptide MHC-II binding scorea Allele
(Human Leukocyte Antigen [HLA] specific)
Antigenic Scoreb
55 EVRSYYYHASVTDIS 0.25–1.76 DRB1*03:05,DRB1*04:01,DRB1*04:08,DRB1*04:09,DRB1*04:07,DRB1*04:21,
DRB1*04:17,DRB1*04:26,DRB1*04:62,DRB1*04:69,DRB1*04:74,DRB1*04:82,
DRB1*07:03,DRB1*07:01,DRB1*08:04,DRB1*09:07,DRB1*09:04,DRB1*09:01,
DRB1*09:09,DRB1*11:02,DRB1*11:21,DRB1*13:22,DRB1*15:06,DRB1*15:02
0.9127
95 GFTDRGWGKGCGLFG 5.37–17.95 DRB1*01:02,DRB1*03:05,DRB1*07:03,DRB1*08:01,DRB1*11:01,DRB1*11:28,
DRB1*13:05,DRB1*13:21,DRB1*15:02,DRB1*15:06,DRB5*01:05
0.9232
380 DSYIVVGRKDKQINH 0.1–1.97 DRB1*03:06,DRB1*03:05,DRB1*03:01,DRB1*03:08,DRB1*03:07,DRB1*08:01,
DRB1*08:04,DRB1*08:06,DRB1*11:01,DRB1*11:07,DRB1*13:07,DRB1*13:04,
DRB5*01:01,DRB5*01:05
1.5861
383 IVVGRKDKQINHHRH 0.4–4.04 DRB1*03:06,DRB1*03:05,DRB1*03:01,DRB1*03:08,DRB1*03:07,DRB1*04:02,
DRB1*08:01,DRB1*08:04,DRB1*08:06,DRB1*08:13,DRB1*11:02,DRB1*11:07,
DRB1*11:21,DRB1*13:01,DRB1*13:04,DRB1*13:27,DRB1*13:22
1.1724
  1. aPercentile score vary in allele specific manner. The less the score better is the binding. The range of scores was obtained by setting cut off. bAntigenic score was computed using Doytchinova and Flower's (2007) method [47]
  2. Epitopes were further checked for their efficacy in interactions at the peptide binding groove (see below)