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Fig. 1 | BMC Immunology

Fig. 1

From: Lipopolysaccharide mediates immuno-pathological alterations in young chicken liver through TLR4 signaling

Fig. 1

Effect of lipopolysaccharide on histomorphology and ALT activity and in chicken liver. Following intraperitoneal LPS treatment in chickens at different time points, H&E staining was performed on liver serial tissue sections. Stellate macrophages (Kupffer cells) in perisinusoidal areas , diffuse infiltration of fat vacuoles indicating fatty infiltration , dilated central vein and sinusoidal capillaries , reduction in size of a few hepatocytes , dissociated liver cells from each other in hepatic cords , dilated hepatic sinusoids along with fibrocytes proliferation in perisinusoidal areas , intracytoplasmic infiltration of variable size and shape fat vacuoles , dilated hepatic sinusoids , infiltration of oval shaped nucleated RBCs ⑩, cytoplasmic fat vacuoles have pushed hepatocyte nuclei at periphery ⑪, reduction in size of a few hepatocytes ⑫ and intense inflammatory cells infiltration around the portal area ⑬ (a). After LPS stimulation, alanine aminotransferase (ALT) activity was measured from liver tissues at 0 h, 2 h, 6 h, 12 h, 24 h, 36 h, 72 h and 120 h by ELISA technique (b). The letter C represents saline (control) group and L represents LPS group. The numbers represent the hours after stimulation. **P < 0.01

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