BMC Immunology

Table 4 Impact of disease activity by organ systems assessed through the SELENA-SLEDAI on health-related quality of life outcomes in 252 patients with systemic lupus erythematosus

From: Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

Predictors	Outcomes
Unadjusted (N = 252)	PF		RP		BP		GH		VT		SF		RE		MH
SLEDAI organ group	B	p	B	p	B	p	B	p	B	p	B	p	B	P	B	p
Musculoskeletal	−6.75	0.11	−18.45	0.008	−21.89	<0.001	−4.84	0.15	−4.01	0.23	−8.80	0.032	−20.27	0.005	−6.85	0.027
Vascular	−27.12	0.019	−39.45	0.040	−12.96	0.32	−7.51	0.43	−7.13	0.44	−4.79	0.68	−32.58	0.11	1.47	0.86
Renal	−5.35	0.16	−20.68	0.001	−10.07	0.02	−1.87	0.54	−6.88	0.022	−9.99	0.007	−24.41	<0.001	−3.00	0.29
Immunologic	1.88	0.56	−4.96	0.36	2.24	0.54	0.04	0.99	−4.67	0.070	−2.08	0.51	−8.06	0.15	−4.14	0.084
Adjusted^a (N = 225)	PF		RP		BP		GH		VT		SF		RE		MH
SLEDAI organ group	B	P	B	P	B	p	B	P	B	P	B	P	B	P	B	P
Musculoskeletal	−7.40	0.069	−16.29	0.020	−21.85	<0.001	−3.77	0.27	−3.40	0.32	−8.39	0.050	−17.60	0.019	−6.35	0.038
Vascular	−15.29	0.22	−34.71	0.10	−6.98	0.63	−4.56	0.66	−6.24	0.54	−1.76	0.89	−32.29	0.16	−1.75	0.85
Renal	−6.41	0.09	−21.99	0.001	−11.57	0.01	−1.52	0.63	−7.26	0.022	−9.89	0.012	−25.47	<0.001	−2.43	0.40
Immunologic	−1.83	0.59	−6.60	0.26	−0.68	0.86	−0.97	0.73	−6.09	0.030	−3.34	0.35	−8.06	0.19	−5.14	0.041

B Regression coefficient: Difference in the SF-36 subscale in patients with organ dysfunction, PF physical function, RP role physical, BP bodily pain, GH general health, VT vitality, SF social function, RE role emotional, MH mental health, SELENA-SLEDAI Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score with the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)
^aAdjusted for sex, age, disease duration

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ISSN: 1471-2172

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