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Table 4 Impact of disease activity by organ systems assessed through the SELENA-SLEDAI on health-related quality of life outcomes in 252 patients with systemic lupus erythematosus

From: Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

Predictors Outcomes
Unadjusted (N = 252) PF RP BP GH VT SF RE MH
SLEDAI organ group B p B p B p B p B p B p B P B p
Musculoskeletal −6.75 0.11 −18.45 0.008 −21.89 <0.001 −4.84 0.15 −4.01 0.23 −8.80 0.032 −20.27 0.005 −6.85 0.027
Vascular −27.12 0.019 −39.45 0.040 −12.96 0.32 −7.51 0.43 −7.13 0.44 −4.79 0.68 −32.58 0.11 1.47 0.86
Renal −5.35 0.16 −20.68 0.001 −10.07 0.02 −1.87 0.54 −6.88 0.022 −9.99 0.007 −24.41 <0.001 −3.00 0.29
Immunologic 1.88 0.56 −4.96 0.36 2.24 0.54 0.04 0.99 −4.67 0.070 −2.08 0.51 −8.06 0.15 −4.14 0.084
Adjusteda (N = 225) PF RP BP GH VT SF RE MH
SLEDAI organ group B P B P B p B P B P B P B P B P
Musculoskeletal −7.40 0.069 −16.29 0.020 −21.85 <0.001 −3.77 0.27 −3.40 0.32 −8.39 0.050 −17.60 0.019 −6.35 0.038
Vascular −15.29 0.22 −34.71 0.10 −6.98 0.63 −4.56 0.66 −6.24 0.54 −1.76 0.89 −32.29 0.16 −1.75 0.85
Renal −6.41 0.09 −21.99 0.001 −11.57 0.01 −1.52 0.63 −7.26 0.022 −9.89 0.012 −25.47 <0.001 −2.43 0.40
Immunologic −1.83 0.59 −6.60 0.26 −0.68 0.86 −0.97 0.73 −6.09 0.030 −3.34 0.35 −8.06 0.19 −5.14 0.041
  1. B Regression coefficient: Difference in the SF-36 subscale in patients with organ dysfunction, PF physical function, RP role physical, BP bodily pain, GH general health, VT vitality, SF social function, RE role emotional, MH mental health, SELENA-SLEDAI Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score with the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA)
  2. aAdjusted for sex, age, disease duration